akt2.S v-akt murine thymoma viral oncogene homolog 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: akt2.S
Official Full Name: v-akt murine thymoma viral oncogene homolog 2 S homeolog
Primary source: Xenbase:XB-GENE-17345542
Locus tag: XELAEV_18042517mg
See related: EnsemblRapid:ENSXLAG00005009607 AllianceGenome:Xenbase:XB-GENE-17345542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pkbb; pkbss; prkbb; akt2-b; v-akt2; pkbbeta; rac-beta
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to act upstream of or within positive regulation of protein targeting to membrane. Predicted to be located in cell cortex and ruffle membrane. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8S

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (84128303..84163597, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (81748506..81783757, complement)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RAC-beta serine/threonine-protein kinase B

Names: PKB beta-B; RAC-PK-beta-B; protein kinase Akt-2-B; protein kinase B, beta-B

NP_001085101.1

EC 2.7.11.1

XP_018087457.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091632.1 → NP_001085101.1 RAC-beta serine/threonine-protein kinase B

See identical proteins and their annotated locations for NP_001085101.1

Status: PROVISIONAL

Source sequence(s)

BC072041

UniProtKB/Swiss-Prot

Q6IP76

Conserved Domains (4) summary

cd05595
Location:160 → 482

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

smart00220
Location:156 → 413

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:4 → 112

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

pfam00169
Location:6 → 105

PH; PH domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

84128303..84163597 complement

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GenBank, FASTA, Sequence Viewer (Graphics)