add3.L adducin 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: add3.L
Official Full Name: adducin 3 L homeolog
Primary source: Xenbase:XB-GENE-5923087
Locus tag: XELAEV_18034201mg
See related: EnsemblRapid:ENSXLAG00005028920 AllianceGenome:Xenbase:XB-GENE-5923087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: add3
Summary: Predicted to enable actin filament binding activity. Predicted to act upstream of or within barbed-end actin filament capping. Predicted to be located in cytoskeleton; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 3. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 7L

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (734485..762218)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (691119..729988)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adducin 3 L homeolog

Names: adducin 3 (gamma)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091606.1 → NP_001085075.1 adducin 3 L homeolog

See identical proteins and their annotated locations for NP_001085075.1

Status: PROVISIONAL

Source sequence(s)

BC098967

UniProtKB/TrEMBL

A0A974HAV4, Q4KLW7, Q6IP90

Related

ENSXLAP00005086284.1, ENSXLAT00005087946.1

Conserved Domains (1) summary

cl00214
Location:132 → 383

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...