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frs3.S fibroblast growth factor receptor substrate 3 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 432079, updated on 4-Nov-2024

Summary

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Official Symbol
frs3.S
Official Full Name
fibroblast growth factor receptor substrate 3 S homeolog
Primary source
Xenbase:XB-GENE-865196
Locus tag
XELAEV_18014891mg
See related
EnsemblRapid:ENSXLAG00005001649 AllianceGenome:Xenbase:XB-GENE-865196
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
frs3
Summary
Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to act upstream of or within fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See frs3.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (60109257..60128010)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (56061326..56079346)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene provisional ortholog of predicted gene 15246 S homeolog Neighboring gene prickle homolog 4 S homeolog Neighboring gene provisional ortholog of progastricsin S homeolog Neighboring gene myb-related transcription factor, partner of profilin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites. Kim YJ, et al. Dev Biol, 2015 Jan 1. PMID 25446028
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. signaling via Pax6 expression through Shp2-binding sites of XFrs3 is necessary for the eye development in Xenopus laevis
    Title: Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC82242

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor substrate 3 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091546.1 → NP_001085015.1  fibroblast growth factor receptor substrate 3 S homeolog

    See identical proteins and their annotated locations for NP_001085015.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071027
    UniProtKB/TrEMBL
    A0A974DJ98, Q6IR73
    Related
    ENSXLAP00005004903.1, ENSXLAT00005005009.1
    Conserved Domains (1) summary
    cd01202
    Location:13 → 104
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    60109257..60128010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041583074.1 → XP_041439008.1  fibroblast growth factor receptor substrate 3 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DJ98, Q6IR73
    Conserved Domains (1) summary
    cd01202
    Location:13 → 104
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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