kpna3.L karyopherin alpha 3 (importin alpha 4) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kpna3.L
Official Full Name: karyopherin alpha 3 (importin alpha 4) L homeolog
Primary source: Xenbase:XB-GENE-953234
Locus tag: XELAEV_18013655mg
See related: EnsemblRapid:ENSXLAG00005028490 AllianceGenome:Xenbase:XB-GENE-953234
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: srp1; srp4; ipoa4; kpna3; srp1gamma
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to act upstream of or within NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (157838112..157869120, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (151933055..151964117, complement)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NLS-bearing protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: karyopherin alpha 3 (importin alpha 4) L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093792.1 → NP_001087261.1 karyopherin alpha 3 (importin alpha 4) L homeolog

See identical proteins and their annotated locations for NP_001087261.1

Status: PROVISIONAL

Source sequence(s)

BC070983

UniProtKB/TrEMBL

A0A974DQ30, Q6IRB7

Related

ENSXLAP00005084798.1, ENSXLAT00005086459.1

Conserved Domains (4) summary

COG5064
Location:2 → 521

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:242 → 355

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:9 → 93

IBB; Importin beta binding domain

sd00043
Location:244 → 269

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

157838112..157869120 complement

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GenBank, FASTA, Sequence Viewer (Graphics)