rdh10.S retinol dehydrogenase 10 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rdh10.S
Official Full Name: retinol dehydrogenase 10 S homeolog
Primary source: Xenbase:XB-GENE-6251537
Locus tag: XELAEV_18033799mg
See related: EnsemblRapid:ENSXLAG00005025422 AllianceGenome:Xenbase:XB-GENE-6251537
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rdh10; XRDH10; rdh10b; SDR16C4; XRDH10a; XRDH10b; rdh10-a; rdh10-b
Summary: Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to act upstream of or within retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Is expressed in several structures, including cardiovascular system; mesenchyme; nervous system; pharyngeal arch; and primary germ layer. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6S

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (106818014..106840189)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (98156997..98179274)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of XRDH10 and XRALDH2 by specific antisense morpholino oligonucleotides had the opposite effects on organizer gene expression, and caused a ventralized phenotype and anteriorization of the brain.
Title: Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinol dehydrogenase 10-B

Names: retinol dehydrogenase 10 (all-trans) S homeolog

NP_001084938.1

EC 1.1.1.300

XP_018124175.1

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091469.1 → NP_001084938.1 retinol dehydrogenase 10-B

See identical proteins and their annotated locations for NP_001084938.1

Status: PROVISIONAL

Source sequence(s)

BC070608

UniProtKB/Swiss-Prot

Q6NRV4

UniProtKB/TrEMBL

A0A974CKB4, C3TWL9

Related

ENSXLAP00005075621.1, ENSXLAT00005077201.1

Conserved Domains (2) summary

cd05339
Location:38 → 307

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

pfam00106
Location:37 → 252

adh_short; short chain dehydrogenase