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agap1.L ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431967, updated on 4-Nov-2024

Summary

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Official Symbol
agap1.L
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 L homeolog
Primary source
Xenbase:XB-GENE-981026
Locus tag
XELAEV_18044834mg
See related
EnsemblRapid:ENSXLAG00005022015 AllianceGenome:Xenbase:XB-GENE-981026
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
agap1; ggap1; centg2
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activator activity; and GTPase activity. Predicted to act upstream of or within activation of GTPase activity and protein transport. Predicted to be located in cytoplasm. Orthologous to human AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See agap1.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (83249272..83506841, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (72749084..73008105, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene gastrulation brain homeobox 2, gene 2 L homeolog Neighboring gene gastrulation brain homeobox 2, gene 1 L homeolog Neighboring gene transient receptor potential cation channel, subfamily M, member 8 L homeolog Neighboring gene transient receptor potential cation channel subfamily M member 8b L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC83730

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
Names
AGAP-1
centaurin-gamma-2
cnt-g2
NP_001084915.1
XP_018089741.1
XP_018089744.1
XP_041431512.1
XP_041431513.1
XP_041431514.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091446.1 → NP_001084915.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

    See identical proteins and their annotated locations for NP_001084915.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070738
    UniProtKB/Swiss-Prot
    Q6NRL1
    Related
    ENSXLAP00005064794.1, ENSXLAT00005066308.1
    Conserved Domains (8) summary
    cd04103
    Location:72 → 229
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00173
    Location:73 → 235
    RAS; Ras subfamily of RAS small GTPases
    cd00204
    Location:742 → 825
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:344 → 595
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:347 → 411
    PH; PH domain
    pfam01412
    Location:614 → 728
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:739 → 829
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:739 → 769
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    83249272..83506841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041575580.1 → XP_041431514.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8J1LQI6
    Conserved Domains (5) summary
    cd04103
    Location:72 → 229
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PTZ00322
    Location:760 → 865
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd01250
    Location:344 → 620
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:764 → 794
    ANK; ANK repeat [structural motif]
    cd08836
    Location:639 → 745
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

  2. XM_041575579.1 → XP_041431513.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8J1LPL1
    Related
    ENSXLAP00005064765.1, ENSXLAT00005066278.1
    Conserved Domains (5) summary
    cd04103
    Location:72 → 233
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PTZ00322
    Location:764 → 869
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd01250
    Location:348 → 624
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:768 → 798
    ANK; ANK repeat [structural motif]
    cd08836
    Location:643 → 749
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

  3. XM_041575578.1 → XP_041431512.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1LPP4, A0A974H3N0
    Conserved Domains (5) summary
    cd04103
    Location:381 → 538
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    PTZ00322
    Location:1069 → 1174
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    cd01250
    Location:653 → 929
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:1073 → 1103
    ANK; ANK repeat [structural motif]
    cd08836
    Location:948 → 1054
    ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

  4. XM_018234255.2 → XP_018089744.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J0TSY0, A0A974H3N0
    Related
    ENSXLAP00005064652.1, ENSXLAT00005066166.1

  5. XM_018234252.2 → XP_018089741.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8J0TRV3, A0A974H3N0
    Related
    ENSXLAP00005064676.1, ENSXLAT00005066190.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NRL1.1 GenPept UniProtKB/Swiss-Prot:Q6NRL1

Gene LinkOut

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