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dcaf8.S DDB1 and CUL4 associated factor 8 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431952, updated on 4-Nov-2024

Summary

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Official Symbol
dcaf8.S
Official Full Name
DDB1 and CUL4 associated factor 8 S homeolog
Primary source
Xenbase:XB-GENE-989777
Locus tag
XELAEV_18042819mg
See related
EnsemblRapid:ENSXLAG00005024388 AllianceGenome:Xenbase:XB-GENE-989777
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
h326; dcaf8; wdr42a; wdr42b; dcaf8l1
Summary
Predicted to be located in cytoplasm and nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dcaf8.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (99971166..99989232, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (94945747..94963875, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene calsequestrin 1 S homeolog Neighboring gene proliferation and apoptosis adaptor protein 15 S homeolog Neighboring gene peroxisomal biogenesis factor 19 S homeolog Neighboring gene cdc42 small effector 1 S homeolog Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC83816

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 8
Names
DDB1 and CUL4 associated factor 8-like 1
DDB1- and CUL4-associated factor 8-like protein 1
WD repeat-containing protein 42A
WD repeat-containing protein 42B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091432.1 → NP_001084901.1  DDB1- and CUL4-associated factor 8

    See identical proteins and their annotated locations for NP_001084901.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070779
    UniProtKB/Swiss-Prot
    Q6NRH1
    Related
    ENSXLAP00005072262.1, ENSXLAT00005073809.1
    Conserved Domains (3) summary
    COG2319
    Location:192 → 549
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:201 → 237
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:188 → 508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    99971166..99989232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018231953.2 → XP_018087442.1  DDB1- and CUL4-associated factor 8 isoform X1

    UniProtKB/TrEMBL
    A0A1L8F4R5, A0A974C523
    Related
    ENSXLAP00005072429.1, ENSXLAT00005073978.1

  2. XM_018231954.2 → XP_018087443.1  DDB1- and CUL4-associated factor 8 isoform X1

    UniProtKB/TrEMBL
    A0A1L8F4R5, A0A974C523

  3. XM_018231952.2 → XP_018087441.1  DDB1- and CUL4-associated factor 8 isoform X1

    UniProtKB/TrEMBL
    A0A1L8F4R5, A0A974C523
    Related
    ENSXLAP00005072538.1, ENSXLAT00005074087.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NRH1.1 GenPept UniProtKB/Swiss-Prot:Q6NRH1

Gene LinkOut

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