U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

garem1.S GRB2 associated regulator of MAPK1 subtype 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431942, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
garem1.S
Official Full Name
GRB2 associated regulator of MAPK1 subtype 1 S homeolog
Primary source
Xenbase:XB-GENE-976988
Locus tag
XELAEV_18033688mg
See related
EnsemblRapid:ENSXLAG00005026550 AllianceGenome:Xenbase:XB-GENE-976988
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
garem; fam59a; garem1
Summary
Predicted to enable proline-rich region binding activity. Predicted to act upstream of or within several processes, including cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; and positive regulation of ERK1 and ERK2 cascade. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See garem1.S in Genome Data Viewer
Location:
chromosome: 6S
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (97607062..97688720, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (88931770..89013906, complement)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene meprin A subunit beta S homeolog Neighboring gene uncharacterized LOC121395155 Neighboring gene RAB10, member RAS oncogene family like S homeolog Neighboring gene PNMA family member 1 S homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC83885

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables proline-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GRB2-associated and regulator of MAPK protein
Names
GRB2 associated, regulator of MAPK1
GRB2-associated and regulator of MAPK1
family with sequence similarity 59, member A
protein FAM59A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091422.1 → NP_001084891.1  GRB2-associated and regulator of MAPK protein

    See identical proteins and their annotated locations for NP_001084891.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070811
    UniProtKB/Swiss-Prot
    Q6NRE4
    UniProtKB/TrEMBL
    A0A974HE92
    Related
    ENSXLAP00005078922.1, ENSXLAT00005080513.1
    Conserved Domains (2) summary
    cd09525
    Location:808 → 874
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:29 → 309
    CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    97607062..97688720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NRE4.1 GenPept UniProtKB/Swiss-Prot:Q6NRE4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.