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bcl9.L BCL9 transcription coactivator L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431941, updated on 4-Nov-2024

Summary

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Official Symbol
bcl9.L
Official Full Name
BCL9 transcription coactivator L homeolog
Primary source
Xenbase:XB-GENE-865416
Locus tag
XELAEV_18011365mg
See related
EnsemblRapid:ENSXLAG00005034485 AllianceGenome:Xenbase:XB-GENE-865416
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
lgs; bcl9; xbcl9; legless
Summary
Predicted to enable beta-catenin binding activity and transcription coactivator activity. Predicted to act upstream of or within canonical Wnt signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Is expressed in ectoderm; nervous system; pharyngeal arch; and visual system. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bcl9.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (7982773..8148614, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (7776832..7807029, complement)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene gap junction protein alpha 8 L homeolog Neighboring gene gap junction protein alpha 5 L homeolog Neighboring gene transmembrane serine protease 3 L homeolog Neighboring gene trefoil factor 3, gene 1 L homeolog Neighboring gene trefoil factor 3, gene 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Kennedy MW, et al. Dev Dyn, 2010 Jan. PMID 19877304
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both XBcl9 and XPygo2 are required to induce supernumerary axis and dorsal gene activation in Xenopus embryos.
    Title: A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC83888

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BCL9 transcription coactivator L homeolog
Names
B cell CLL/lymphoma 9 L homeolog
B-cell lymphoma 9
B-cell lymphoma 9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091421.1 → NP_001084890.1  BCL9 transcription coactivator L homeolog

    See identical proteins and their annotated locations for NP_001084890.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070813
    UniProtKB/TrEMBL
    Q6NRE2
    Conserved Domains (2) summary
    TIGR01628
    Location:476 → 583
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam11502
    Location:344 → 382
    BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    7982773..8148614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041580939.1 → XP_041436873.1  BCL9 transcription coactivator L homeolog isoform X1

    UniProtKB/TrEMBL
    D0EUZ9
    Related
    ENSXLAP00005103334.1, ENSXLAT00005105339.1
    Conserved Domains (4) summary
    TIGR01628
    Location:541 → 648
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    PHA03247
    Location:935 → 1260
    PHA03247; large tegument protein UL36; Provisional
    pfam09606
    Location:642 → 1043
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11502
    Location:409 → 447
    BCL9; B-cell lymphoma 9 protein

  2. XM_041580940.1 → XP_041436874.1  BCL9 transcription coactivator L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1M5B2
    Conserved Domains (4) summary
    TIGR01628
    Location:540 → 647
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    PHA03247
    Location:934 → 1259
    PHA03247; large tegument protein UL36; Provisional
    pfam09606
    Location:641 → 1042
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11502
    Location:408 → 446
    BCL9; B-cell lymphoma 9 protein

  3. XM_041580941.1 → XP_041436875.1  BCL9 transcription coactivator L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A1L8HC43, A0A974DM46
    Related
    ENSXLAP00005103228.1, ENSXLAT00005105233.1
    Conserved Domains (4) summary
    TIGR01628
    Location:541 → 648
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    pfam05109
    Location:921 → 1075
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam09606
    Location:945 → 1336
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11502
    Location:409 → 447
    BCL9; B-cell lymphoma 9 protein

  4. XM_041580937.1 → XP_041436871.1  BCL9 transcription coactivator L homeolog isoform X1

    UniProtKB/TrEMBL
    D0EUZ9
    Related
    ENSXLAP00005103165.1, ENSXLAT00005105170.1
    Conserved Domains (4) summary
    TIGR01628
    Location:541 → 648
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    PHA03247
    Location:935 → 1260
    PHA03247; large tegument protein UL36; Provisional
    pfam09606
    Location:642 → 1043
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11502
    Location:409 → 447
    BCL9; B-cell lymphoma 9 protein

  5. XM_041580938.1 → XP_041436872.1  BCL9 transcription coactivator L homeolog isoform X1

    UniProtKB/TrEMBL
    D0EUZ9
    Related
    ENSXLAP00005103254.1, ENSXLAT00005105259.1
    Conserved Domains (4) summary
    TIGR01628
    Location:541 → 648
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    PHA03247
    Location:935 → 1260
    PHA03247; large tegument protein UL36; Provisional
    pfam09606
    Location:642 → 1043
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam11502
    Location:409 → 447
    BCL9; B-cell lymphoma 9 protein
Nucleotide Protein Strain
Heading Accession and Version

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