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ptpn4.S protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431920, updated on 4-Nov-2024

Summary

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Official Symbol
ptpn4.S
Official Full Name
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) S homeolog
Primary source
Xenbase:XB-GENE-995934
Locus tag
XELAEV_18046946mg
See related
EnsemblRapid:ENSXLAG00005017011 AllianceGenome:Xenbase:XB-GENE-995934
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ptpn4
Summary
Predicted to enable cytoskeletal protein binding activity and protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasm; cytoplasmic side of plasma membrane; and cytoskeleton. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ptpn4.S in Genome Data Viewer
Location:
chromosome: 9_10S
Exon count:
29
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (49576645..49624604, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (42917480..42965925, complement)

Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene kalirin RhoGEF kinase S homeolog Neighboring gene erythrocyte membrane protein band 4.1 like 5 S homeolog Neighboring gene fibrinogen-like protein 1-like protein Neighboring gene transmembrane protein 177-like Neighboring gene muscle RAS oncogene homolog S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC83117

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091402.1 → NP_001084871.1  protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) S homeolog

    See identical proteins and their annotated locations for NP_001084871.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070687
    UniProtKB/TrEMBL
    Q6DCH9, Q6NRP9
    Conserved Domains (8) summary
    smart00194
    Location:660 → 913
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:685 → 912
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:518 → 605
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd14473
    Location:122 → 214
    FERM_B-lobe; FERM domain B-lobe
    pfam08736
    Location:325 → 365
    FA; FERM adjacent (FA)
    pfam09379
    Location:33 → 97
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    49576645..49624604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018237411.2 → XP_018092900.1  protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0TYY6, Q6DCH9
    Related
    ENSXLAP00005050256.1, ENSXLAT00005051397.1

  2. XM_041577731.1 → XP_041433665.1  protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LY46, A0A974BUE8
    Related
    ENSXLAP00005050151.1, ENSXLAT00005051292.1
    Conserved Domains (4) summary
    smart00295
    Location:75 → 267
    B41; Band 4.1 homologues
    cd00992
    Location:563 → 650
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:261 → 355
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cl28904
    Location:689 → 962
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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