U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ptpn12.S protein tyrosine phosphatase non-receptor type 12 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431887, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ptpn12.S
Official Full Name
protein tyrosine phosphatase non-receptor type 12 S homeolog
Primary source
Xenbase:XB-GENE-942128
Locus tag
XELAEV_18020964mg
See related
EnsemblRapid:ENSXLAG00005009392 AllianceGenome:Xenbase:XB-GENE-942128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ptpn12; PTP-PEST; PTP-PESTr
Summary
Predicted to enable non-membrane spanning protein tyrosine phosphatase activity. Predicted to act upstream of or within cellular response to epidermal growth factor stimulus; peptidyl-tyrosine dephosphorylation; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ptpn12.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (72515738..72569917, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (71103485..71157820, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 60 S homeolog Neighboring gene round spermatid basic protein 1 like S homeolog Neighboring gene fibrinogen like 2 S homeolog Neighboring gene uncharacterized LOC121402183

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC81122

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein tyrosine phosphatase non-receptor type 12 S homeolog
Names
protein tyrosine phosphatase PTP-PEST
NP_001084841.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091372.1 → NP_001084841.1  protein tyrosine phosphatase non-receptor type 12 S homeolog

    See identical proteins and their annotated locations for NP_001084841.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070582
    UniProtKB/TrEMBL
    A0A974DA67, Q6NRX7
    Related
    ENSXLAP00005027424.1, ENSXLAT00005028156.1
    Conserved Domains (1) summary
    cd14604
    Location:2 → 298
    PTPc-N12; catalytic domain of tyrosine-protein phosphatase non-receptor type 12

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    72515738..72569917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials