racgap1.L Rac GTPase activating protein 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: racgap1.L
Official Full Name: Rac GTPase activating protein 1 L homeolog
Primary source: Xenbase:XB-GENE-943989
Locus tag: XELAEV_18013636mg
See related: EnsemblRapid:ENSXLAG00005033942 AllianceGenome:Xenbase:XB-GENE-943989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cyk-4; id-gap; racgap1; mgcracgap
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to act upstream of or within Rho protein signal transduction; mitotic cytokinesis; and mitotic spindle midzone assembly. Predicted to be located in several cellular components, including cleavage furrow; midbody; and spindle midzone. Predicted to be part of centralspindlin complex. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (156826980..156847947, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (150919704..150940841, complement)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MgcRacGAP SxIP motif is functionally important both for its role in regulating adherens junction structure during interphase and for regulating Rho GTPase activity during cytokinesis.
Title: The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic spindle midzone assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of centralspindlin complex	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rac GTPase activating protein 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091351.1 → NP_001084820.1 Rac GTPase activating protein 1 L homeolog

See identical proteins and their annotated locations for NP_001084820.1

Status: PROVISIONAL

Source sequence(s)

BC070771

UniProtKB/TrEMBL

A0A974HZM5, Q6NRH9

Related

ENSXLAP00005101332.1, ENSXLAT00005103309.1

Conserved Domains (2) summary

cd00029
Location:286 → 334

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:345 → 538

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

156826980..156847947 complement

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GenBank, FASTA, Sequence Viewer (Graphics)