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sh3rf1.S SH3 domain containing ring finger 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431855, updated on 17-Aug-2024

Summary

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Official Symbol
sh3rf1.S
Official Full Name
SH3 domain containing ring finger 1 S homeolog
Primary source
Xenbase:XB-GENE-950810
Locus tag
XELAEV_18009169mg
See related
EnsemblRapid:ENSXLAG00005001188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
posh; rnf142; sh3md2; sh3rf1
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Genomic context

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Location:
chromosome: 1S
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (39274979..39376656)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (39019360..39121144)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 3 S homeolog Neighboring gene NIMA-related kinase 1 S homeolog Neighboring gene carbonyl reductase family member 4-like Neighboring gene palladin, cytoskeletal associated protein S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The assembly of POSH-JNK regulates Xenopus anterior neural development. Kim GH, et al. Dev Biol, 2005 Oct 1. PMID 16125690
  2. Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes. Kim GH, et al. Cell Signal, 2006 Apr. PMID 16084064
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of CD8-positive, alpha-beta T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase SH3RF1
Names
Protein POSH
RING-type E3 ubiquitin transferase SH3RF1
SH3 domain-containing RING finger protein 1
plenty of SH3s
putative E3 ubiquitin-protein ligase SH3RF1
xPOSH
NP_001084814.1
XP_018091419.1
XP_041430754.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091345.1 → NP_001084814.1  E3 ubiquitin-protein ligase SH3RF1

    See identical proteins and their annotated locations for NP_001084814.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070823
    UniProtKB/Swiss-Prot
    Q3L1I1, Q6NRD3
    UniProtKB/TrEMBL
    A0A974I0K8
    Related
    ENSXLAP00005003622.1, ENSXLAT00005003684.1
    Conserved Domains (5) summary
    cd11785
    Location:771 → 825
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11926
    Location:402 → 456
    SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
    cd11927
    Location:135 → 188
    SH3_SH3RF1_1; First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd00162
    Location:11 → 56
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl17036
    Location:198 → 252
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    39274979..39376656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018235930.2 → XP_018091419.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LNI9, A0A974I0K8
    Conserved Domains (6) summary
    cd11785
    Location:788 → 842
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11926
    Location:414 → 468
    SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
    cd11927
    Location:147 → 200
    SH3_SH3RF1_1; First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    PRK07003
    Location:467 → 608
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16748
    Location:20 → 67
    RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
    cl17036
    Location:210 → 264
    SH3; Src Homology 3 domain superfamily

  2. XM_041574820.1 → XP_041430754.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

    UniProtKB/TrEMBL
    A0A8J1LNI9, A0A974I0K8
    Conserved Domains (6) summary
    cd11785
    Location:788 → 842
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11926
    Location:414 → 468
    SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
    cd11927
    Location:147 → 200
    SH3_SH3RF1_1; First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    PRK07003
    Location:467 → 608
    PRK07003; DNA polymerase III subunit gamma/tau
    cd16748
    Location:20 → 67
    RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
    cl17036
    Location:210 → 264
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NRD3.1 GenPept UniProtKB/Swiss-Prot:Q6NRD3

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