emc1.L ER membrane protein complex subunit 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: emc1.L
Official Full Name: ER membrane protein complex subunit 1 L homeolog
Primary source: Xenbase:XB-GENE-1010285
Locus tag: XELAEV_18036414mg
See related: EnsemblRapid:ENSXLAG00005015942 AllianceGenome:Xenbase:XB-GENE-1010285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: emc1; kiaa0090
Summary: Predicted to contribute to membrane insertase activity. Predicted to act upstream of or within protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Human ortholog(s) of this gene implicated in cerebellar atrophy, visual impairment, and psychomotor retardation. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (136263437..136287825)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (121145197..121169373, complement)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein folding in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IEA Inferred from Electronic Annotation more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ER membrane protein complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091342.1 → NP_001084811.1 ER membrane protein complex subunit 1 precursor

See identical proteins and their annotated locations for NP_001084811.1

Status: PROVISIONAL

Source sequence(s)

BC070840

UniProtKB/Swiss-Prot

Q6NRB9

UniProtKB/TrEMBL

A0A974CIB3

Related

ENSXLAP00005047056.1, ENSXLAT00005048160.1

Conserved Domains (2) summary

pfam07774
Location:781 → 986

DUF1620; Protein of unknown function (DUF1620)

pfam13360
Location:27 → 165

PQQ_2; PQQ-like domain