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clp1.L cleavage factor polyribonucleotide kinase subunit 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 431824, updated on 4-Nov-2024

Summary

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Official Symbol
clp1.L
Official Full Name
cleavage factor polyribonucleotide kinase subunit 1 L homeolog
Primary source
Xenbase:XB-GENE-1008976
Locus tag
XELAEV_18035071mg
See related
EnsemblRapid:ENSXLAG00005033051 AllianceGenome:Xenbase:XB-GENE-1008976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
clp1
Summary
Predicted to enable ATP binding activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; and ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity. Predicted to act upstream of or within cerebellar cortex development; negative regulation of gene expression; and tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleus. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 10. Orthologous to human CLP1 (cleavage factor polyribonucleotide kinase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clp1.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (61532593..61547183, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (53441835..53456425, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121395456 Neighboring gene zinc finger, DHHC-type containing 5 L homeolog Neighboring gene catenin delta 1 L homeolog Neighboring gene uncharacterized LOC108696306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC78822

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent polynucleotide 5'-hydroxyl-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables polynucleotide 5'-hydroxyl-kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RISC complex assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RISC complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cerebellar cortex development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within global gene silencing by mRNA cleavage ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage factor complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-intron endonuclease complex IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-intron endonuclease complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
polyribonucleotide 5'-hydroxyl-kinase Clp1
Names
CLP1, cleavage and polyadenylation factor I subunit, homolog
cleavage and polyadenylation factor I subunit 1 L homeolog
NP_001084787.1
XP_018079927.1
XP_018079928.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091318.1 → NP_001084787.1  polyribonucleotide 5'-hydroxyl-kinase Clp1

    See identical proteins and their annotated locations for NP_001084787.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070530
    UniProtKB/Swiss-Prot
    Q6NS21
    UniProtKB/TrEMBL
    A0A974CF15
    Related
    ENSXLAP00005098967.1, ENSXLAT00005100818.1
    Conserved Domains (4) summary
    COG5623
    Location:26 → 437
    CLP1; Predicted GTPase subunit of the pre-mRNA cleavage complex [Translation, ribosomal structure and biogenesis]
    pfam06807
    Location:324 → 437
    Clp1; Pre-mRNA cleavage complex II protein Clp1
    pfam16573
    Location:27 → 119
    CLP1_N; N-terminal beta-sandwich domain of polyadenylation factor
    pfam16575
    Location:133 → 318
    CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    61532593..61547183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018224439.2 → XP_018079928.1  polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X2

    UniProtKB/Swiss-Prot
    Q6NS21
    UniProtKB/TrEMBL
    A0A974CF15

  2. XM_018224438.2 → XP_018079927.1  polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X1

    UniProtKB/TrEMBL
    A0A8J0T648, A0A974CF15
    Related
    ENSXLAP00005098910.1, ENSXLAT00005100758.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NS21.1 GenPept UniProtKB/Swiss-Prot:Q6NS21

Gene LinkOut

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