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Trmt61 tRNA methyltransferase 61 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43170, updated on 10-May-2024

Summary

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Official Symbol
Trmt61provided by FlyBase
Official Full Name
tRNA methyltransferase 61provided by FlyBase
Primary source
FLYBASE:FBgn0039407
Locus tag
Dmel_CG14544
See related
AllianceGenome:FB:FBgn0039407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14544; Dmel\CG14544; TRMT61A
Summary
Predicted to enable tRNA (adenine-N1-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Trmt61 in Genome Data Viewer
Location:
96F10-96F10; 3-89 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26059496..26061293)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21885218..21887015)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene Ribosomal protein L34a Neighboring gene Threonyl-carbamoyl synthesis 6 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44950 Neighboring gene dysfusion Neighboring gene long non-coding RNA:CR44319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Shafik AM, et al. Hum Mol Genet, 2022 May 19. PMID 34897434, Free PMC Article
  2. A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. Shen J, et al. Aging (Albany NY), 2009 Jan 30. PMID 20157509, Free PMC Article
  3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
  4. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article
  5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA methyltransferase 61
Names
CG14544-PA
CG14544-PB
Trmt61-PA
Trmt61-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26059496..26061293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143204.3 → NP_651461.1  tRNA methyltransferase 61, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651461.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBH7
    Related
    FBpp0084342
    Conserved Domains (1) summary
    pfam08704
    Location:72 → 310
    GCD14; tRNA methyltransferase complex GCD14 subunit

  2. NM_001316555.1 → NP_001303484.1  tRNA methyltransferase 61, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBH7
    Conserved Domains (1) summary
    pfam08704
    Location:72 → 310
    GCD14; tRNA methyltransferase complex GCD14 subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBH7 Q9VBH7

Gene LinkOut

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