U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DAPK1 death-associated protein kinase 1 [ Gallus gallus (chicken) ]

Gene ID: 431670, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
DAPK1provided by CGNC
Official Full Name
death-associated protein kinase 1provided by CGNC
Primary source
CGNC:65942
See related
Ensembl:ENSGALG00010009744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DAPK1 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
28
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (41891494..41989841)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (41891494..41989841)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417539 Neighboring gene uncharacterized LOC121108364 Neighboring gene uncharacterized LOC101750974 Neighboring gene cathepsin V

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells. Maślikowski BM, et al. J Virol, 2017 Jan 1. PMID 27795443, Free PMC Article
  2. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JunD and AP-1 antagonize the induction of DAPK1 to promote the survival of v-Src-transformed cells.
    Title: JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables TIR domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
death-associated protein kinase 1
NP_001026784.2
NP_001264960.2
XP_015135805.1
XP_015135806.1
XP_040511568.1
XP_040511569.1
XP_046761437.1
XP_046761438.1
XP_046791309.1
XP_046791310.1
XP_046791311.1
XP_046791312.1
XP_046791313.1
XP_046791314.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031613.2 → NP_001026784.2  death-associated protein kinase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' structure which results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAENSK010000094
    UniProtKB/TrEMBL
    Q5F4C6
    Related
    ENSGALP00010013469.1, ENSGALT00010023288.1
    Conserved Domains (4) summary
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:428 → 639
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001278031.2 → NP_001264960.2  death-associated protein kinase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAENSK010000094
    UniProtKB/TrEMBL
    A0A8V0Y7C3
    Related
    ENSGALP00010013472.1, ENSGALT00010023298.1
    Conserved Domains (5) summary
    cd08782
    Location:1309 → 1394
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:428 → 639
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    41891494..41989841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015280319.3 → XP_015135805.1  death-associated protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y7C3
    Conserved Domains (5) summary
    cd08782
    Location:1309 → 1394
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:428 → 639
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_015280320.4 → XP_015135806.1  death-associated protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5NT66
    Conserved Domains (7) summary
    smart00220
    Location:13 → 275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:505 → 629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    pfam12796
    Location:449 → 541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347 → 399
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]

  3. XM_040655635.2 → XP_040511569.1  death-associated protein kinase 1 isoform X4

    Conserved Domains (5) summary
    cd08782
    Location:1235 → 1320
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    sd00045
    Location:338 → 368
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:305 → 357
    Ank_4; Ankyrin repeats (many copies)
    cl21453
    Location:9 → 201
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:354 → 565
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_046905481.1 → XP_046761437.1  death-associated protein kinase 1 isoform X5

  5. XM_046905482.1 → XP_046761438.1  death-associated protein kinase 1 isoform X6

  6. XM_040655634.2 → XP_040511568.1  death-associated protein kinase 1 isoform X3

    Conserved Domains (5) summary
    cd08782
    Location:1290 → 1375
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:2 → 256
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:393 → 423
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:360 → 412
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:409 → 620
    Ank_2; Ankyrin repeats (3 copies)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    41891494..41989841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046935353.1 → XP_046791309.1  death-associated protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y7C3

  2. XM_046935354.1 → XP_046791310.1  death-associated protein kinase 1 isoform X2

  3. XM_046935356.1 → XP_046791312.1  death-associated protein kinase 1 isoform X4

  4. XM_046935357.1 → XP_046791313.1  death-associated protein kinase 1 isoform X5

  5. XM_046935358.1 → XP_046791314.1  death-associated protein kinase 1 isoform X6

  6. XM_046935355.1 → XP_046791311.1  death-associated protein kinase 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials