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E(spl)mdelta-HLH Enhancer of split mdelta, helix-loop-helix [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43150, updated on 2-Nov-2024

Summary

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Official Symbol
E(spl)mdelta-HLHprovided by FlyBase
Official Full Name
Enhancer of split mdelta, helix-loop-helixprovided by FlyBase
Primary source
FLYBASE:FBgn0002734
Locus tag
Dmel_CG8328
See related
AllianceGenome:FB:FBgn0002734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHc14; CG8328; Dmel\CG8328; E(Spl) HLH-m delta; E(spl) mdelta; E(Spl)-HLH-mdelta; E(spl)-mdelta; E(spl)delta; E(spl)mC; E(spl)mdelta; E(spl)Mdelta; HLH-mdelta; HLHmC; HLHMD; HLHmdelta; HLHMdelta; mC; md; mdelta; Mdelta; mdelta0.5
Summary
Enables sequence-specific double-stranded DNA binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of neuroblast proliferation. Predicted to be active in nucleus. Is expressed in several structures, including embryonic segment; epithelium; eye photoreceptor cell; germ layer; and head epidermis primordium. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See E(spl)mdelta-HLH in Genome Data Viewer
Location:
96F9-96F9; 3-89 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25997621..25998633)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21823343..21824355)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neurofibromin 1 Neighboring gene uncharacterized protein Neighboring gene Enhancer of split mgamma, helix-loop-helix Neighboring gene long non-coding RNA:CR45037

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila. Chen PL, et al. Neuron, 2008 Apr 10. PMID 18400160, Free PMC Article
  2. The Notch target E(spl)mδ is a muscle-specific gene involved in methylmercury toxicity in motor neuron development. Engel GL, et al. Neurotoxicol Teratol, 2014 May-Jun. PMID 24632433, Free PMC Article
  3. A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity. Schwabe T, et al. Cell, 2013 Jul 18. PMID 23870124, Free PMC Article
  4. Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Prakash S, et al. Dev Biol, 2009 Dec 1. PMID 19766621, Free PMC Article
  5. Review: myogenic and muscle toxicity targets of environmental methylmercury exposure. Tam LM, et al. Arch Toxicol, 2024 Jun. PMID 38546836,

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in R1/R6 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in R7 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
enhancer of split mdelta, helix-loop-helix
Names
CG8328-PA
E(spl) region
E(spl) region transcript mdelta
E(spl)mdelta-HLH-PA
enhancer of split region transcript HLHmC
split locus enhancer protein mC
transcript mdelta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25997621..25998633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079779.3 → NP_524503.2  enhancer of split mdelta, helix-loop-helix [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524503.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01071, Q01897, Q4V723, Q56MT6, Q56MU1, Q56MU3, Q56MU4, Q56MU6, Q56MU8, Q56MV0, Q56MV5, Q56MV6, Q56MW2, Q56MW7, Q56MW9, Q56MX9, Q56MY0, Q56MY1, Q56N19, Q56N23, Q5S485, Q5S4A9, Q5S4K5
    Related
    FBpp0084328
    Conserved Domains (2) summary
    smart00511
    Location:91 → 135
    ORANGE; Orange domain
    cd19741
    Location:9 → 77
    bHLH-O_ESMB_like; basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster enhancer of split mbeta protein (ESMB) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01071.1 Q01071

Gene LinkOut

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