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MED28 Mediator complex subunit 28 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43079, updated on 18-Sep-2024

Summary

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Official Symbol
MED28provided by FlyBase
Official Full Name
Mediator complex subunit 28provided by FlyBase
Primary source
FLYBASE:FBgn0039337
Locus tag
Dmel_CG5121
See related
AllianceGenome:FB:FBgn0039337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM31575; CG5121; dMED23; Dmel\CG5121; Med23; Med28
Summary
Predicted to contribute to transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Orthologous to human MED28 (mediator complex subunit 28). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See MED28 in Genome Data Viewer
Location:
96E1-96E1; 3-88 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25477003..25477745)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21302725..21303467)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Furin 1 Neighboring gene Mucin 96D Neighboring gene Vacuolar protein sorting 33B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene XNP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The chromatin remodelling factor dATRX is involved in heterochromatin formation. Bassett AR, et al. PLoS One, 2008 May 7. PMID 18461125, Free PMC Article
  2. Tousled-like kinase mediated a new type of cell death pathway in Drosophila. Zhang Y, et al. Cell Death Differ, 2016 Jan. PMID 26088162, Free PMC Article
  3. Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens. Huang C, et al. Front Immunol, 2020. PMID 33746938, Free PMC Article
  4. MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Kim TW, et al. Proc Natl Acad Sci U S A, 2004 Aug 17. PMID 15297616, Free PMC Article
  5. A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia. Azpurua J, et al. PLoS Genet, 2021 Nov. PMID 34723963, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mediator subunits MED16 and MED23 interact with specific activators to coordinate and transfer activator-specific signals to the transcriptional machinery.
    Title: MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to transcription coregulator activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit 28
Names
CG5121-PA
MED28-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25477003..25477745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143140.1 → NP_651397.1  mediator complex subunit 28 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651397.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VBQ9
    Related
    FBpp0084211, FBtr0084836
    Conserved Domains (1) summary
    pfam11594
    Location:39 → 130
    Med28; Mediator complex subunit 28
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBQ9.1 Q9VBQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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