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tobi target of brain insulin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43072, updated on 2-Nov-2024

Summary

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Official Symbol
tobiprovided by FlyBase
Official Full Name
target of brain insulinprovided by FlyBase
Primary source
FLYBASE:FBgn0261575
Locus tag
Dmel_CG11909
See related
AllianceGenome:FB:FBgn0261575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11909; CT33098; Dmel\CG11909; Tobi
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult gut; adult head; and fat cell. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See tobi in Genome Data Viewer
Location:
96D2-96D2; 3-87 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25344761..25346921, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21170483..21172643, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene rha Neighboring gene Furin 1 Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit-like Neighboring gene astrocytic leucine-rich repeat molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms. Williams MJ, et al. Cells, 2022 Mar 11. PMID 35326421, Free PMC Article
  2. Exposure to Titanium Dioxide Nanoparticles Leads to Specific Disorders of Spermatid Elongation via Multiple Metabolic Pathways in Drosophila Testes. Cheng X, et al. ACS Omega, 2024 Jun 4. PMID 38854533, Free PMC Article
  3. Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila. Strilbytska OM, et al. Front Physiol, 2020. PMID 33391017, Free PMC Article
  4. Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues. Zhang S, et al. Int J Mol Sci, 2018 Apr 10. PMID 29642630, Free PMC Article
  5. The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila. Hentze JL, et al. Sci Rep, 2015 Jun 30. PMID 26123697, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
target of brain insulin
Names
CG11909-PA
alpha-Glucosidase
tobi-PA
NP_651391.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25344761..25346921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143134.3 → NP_651391.1  target of brain insulin [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651391.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBR6
    Related
    FBpp0084221
    Conserved Domains (2) summary
    cd06592
    Location:255 → 621
    GH31_NET37; glucosidase NET37
    pfam01055
    Location:246 → 653
    Glyco_hydro_31; Glycosyl hydrolases family 31
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBR6 Q9VBR6

Gene LinkOut

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