Smg6 Smg6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Smg6provided by FlyBase
Official Full Name: Smg6provided by FlyBase
Primary source: FLYBASE:FBgn0039260
Locus tag: Dmel_CG6369
See related: AllianceGenome:FB:FBgn0039260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6369; Dmel\CG6369; DmSmg6; dSMG6; SMG6
Summary: Enables RNA nuclease activity. Involved in neuromuscular synaptic transmission; regulation of gene expression; and synapse organization. Predicted to be located in cytosol. Predicted to be part of telomerase holoenzyme complex. Is expressed in organism. Orthologous to human SMG6 (SMG6 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25029429..25033465, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20855151..20859187, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

SMG6 is a conserved endonuclease that degrades mRNAs terminating translation prematurely in metazoa
Title: SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in miRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of telomerase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info

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