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NEU4 sialidase 4 [ Gallus gallus (chicken) ]

Gene ID: 429131, updated on 17-Aug-2024

Summary

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Official Symbol
NEU4provided by CGNC
Official Full Name
sialidase 4provided by CGNC
Primary source
CGNC:53560
See related
Ensembl:ENSGALG00010024860
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
sialidase-4
Orthologs
human mouse all
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Genomic context

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See NEU4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (4410048..4412415, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (4242931..4245298, complement)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107051864 Neighboring gene ring finger protein 168 Neighboring gene single-pass membrane protein with coiled-coil domains 1 Neighboring gene UBX domain protein 7 Neighboring gene TM4SF19 transmembrane 4 L six family member 19 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene D-2-hydroxyglutarate dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. Giacopuzzi E, et al. PLoS One, 2012. PMID 22952925, Free PMC Article
  2. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. Giacopuzzi E, et al. BMC Biochem, 2011 Aug 23. PMID 21861893, Free PMC Article
  3. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. Monti E, et al. Genomics, 1999 Apr 1. PMID 10191093
  4. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Monti E, et al. Genomics, 2004 Mar. PMID 14962670
  5. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Monti E, et al. Biochem J, 2000 Jul 1. PMID 10861246, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables exo-alpha-sialidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oligosaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sialidase-4
Names
neuraminidase 4
sialidase NEU4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4410048..4412415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015277126.4 → XP_015132612.2  sialidase-4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZV71, K0Q571
    Related
    ENSGALP00010037452.1, ENSGALT00010060693.1
    Conserved Domains (1) summary
    cd15482
    Location:10 → 422
    Sialidase_non-viral; Non-viral sialidases

  2. XM_025153751.3 → XP_025009519.2  sialidase-4 isoform X2

    UniProtKB/TrEMBL
    A0A8V1A0C4
    Related
    ENSGALP00010037454.1, ENSGALT00010060695.1
    Conserved Domains (1) summary
    cd15482
    Location:90 → 502
    Sialidase_non-viral; Non-viral sialidases

  3. XM_025153750.3 → XP_025009518.2  sialidase-4 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A0C4
    Conserved Domains (1) summary
    cd15482
    Location:90 → 526
    Sialidase_non-viral; Non-viral sialidases

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4242931..4245298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040678951.2 → XP_040534885.1  sialidase-4 isoform X3

    UniProtKB/TrEMBL
    K0Q571
    Conserved Domains (1) summary
    cd15482
    Location:10 → 422
    Sialidase_non-viral; Non-viral sialidases

  2. XM_040678949.2 → XP_040534883.1  sialidase-4 isoform X2

    UniProtKB/TrEMBL
    A0A8V1A0C4
    Conserved Domains (1) summary
    cd15482
    Location:90 → 502
    Sialidase_non-viral; Non-viral sialidases

  3. XM_040678948.2 → XP_040534882.1  sialidase-4 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A0C4
    Conserved Domains (1) summary
    cd15482
    Location:90 → 526
    Sialidase_non-viral; Non-viral sialidases
Nucleotide Protein Strain
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