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Orct2 Organic cation transporter 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42890, updated on 22-Aug-2024

Summary

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Official Symbol
Orct2provided by FlyBase
Official Full Name
Organic cation transporter 2provided by FlyBase
Primary source
FLYBASE:FBgn0086365
Locus tag
Dmel_CG13610
See related
AllianceGenome:FB:FBgn0086365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cald; CG13610; Dmel\CG13610; EP(3)1072; EP1072; orct2
Summary
Predicted to enable organic cation transmembrane transporter activity. Involved in positive regulation of cell growth. Predicted to be integral component of membrane. Is expressed in adult head; embryonic proventriculus; extended germ band embryo; larval ventral nerve cord; and procephalic neuroblast. Orthologous to several human genes including SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Orct2 in Genome Data Viewer
Location:
95F8-95F8; 3-84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24273029..24275728)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20098751..20101450)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phenylalanyl-tRNA synthetase, beta-subunit Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1 Neighboring gene Organic cation transporter Neighboring gene sheepish

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies. Gai Y, et al. Neuron, 2016 May 4. PMID 27146270, Free PMC Article
  2. calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Herranz H, et al. Development, 2006 Jul. PMID 16774996
  3. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
  4. Severe Fertility Effects of sheepish Sperm Caused by Failure To Enter Female Sperm Storage Organs in Drosophila melanogaster. Tomaru M, et al. G3 (Bethesda), 2018 Jan 4. PMID 29158336, Free PMC Article
  5. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Petritsch C, et al. Dev Cell, 2003 Feb. PMID 12586070

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify calderon, a gene that encodes a protein with highest homology with organic cation transporters of the major facilitator superfamily, as a new transcriptional target of the insulin receptor pathway
    Title: calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables organic cation transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in organic cation transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
organic cation transporter 2
Names
CG13610-PA
CG13610-PB
EP1072
Orct2-PA
Orct2-PB
calderon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24273029..24275728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275978.2 → NP_001262907.1  organic cation transporter 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262907.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95R48, Q9VCA3
    UniProtKB/TrEMBL
    A0A0B4KHD4, R9QRG4
    Conserved Domains (2) summary
    cd06174
    Location:127 → 503
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 520
    2A0119; cation transport protein

  2. NM_142981.3 → NP_651238.2  organic cation transporter 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651238.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95R48, Q9VCA3
    UniProtKB/TrEMBL
    A0A0B4KHD4, R9QRG4
    Related
    FBpp0083982
    Conserved Domains (2) summary
    cd06174
    Location:127 → 503
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 520
    2A0119; cation transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHD4 A0A0B4KHD4
Q95R48.2 Q95R48

Gene LinkOut

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