jar jaguar [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: jarprovided by FlyBase
Official Full Name: jaguarprovided by FlyBase
Primary source: FLYBASE:FBgn0011225
Locus tag: Dmel_CG5695
See related: AllianceGenome:FB:FBgn0011225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 95F; 95F MHC; CG5695; Dm 95F; Dm95F; Dmel\CG5695; dMyo6; dMyoVI; Dro95F; jag; JAG; Jaguar; Jar; M6; Mhc95F; MHC95F; ms(3)06746; myo VI; Myo1A; myo6; Myosin VI; myosins VI; myoVI; MyoVI; MYOVI
Summary: Enables calmodulin binding activity and cytoskeletal protein binding activity. Involved in several processes, including cytoskeleton organization; germ cell development; and morphogenesis of an epithelium. Located in several cellular components, including germline ring canal; growth cone; and investment cone. Part of microtubule associated complex; myosin VI complex; and sperm individualization complex. Is expressed in several structures, including adult heart; adult thorax; gonad; and head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 95F6-95F8; 3-84 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24252826..24271233, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20078548..20096955, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations support the notion that a major function of Myosin VI in the nerve terminal is tethering synaptic vesicles to proper sub-cellular location within the bouton
Title: Localization and mobility of synaptic vesicles in Myosin VI mutants of Drosophila.
These data demonstrate that generating an organized and functional actin structure in this cell requires multiple activities coordinated by myosin VI.
Title: Myosin VI regulates actin structure specialization through conserved cargo-binding domain sites.
The androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) light chain sites are distinct from those of calmodulin.
Title: Structure of androcam supports specialized interactions with myosin VI.
data indicate that myosin V and VI, but not II, play related but distinct roles in regulating microtubule (MT)-based mitochondrial movement: they oppose, rather than complement, protracted MT-based movements and perhaps facilitate organelle docking
Title: Evidence that myosin activity opposes microtubule-based axonal transport of mitochondria.
Results suggest that myosin VI does not need to dimerize via the predicted coiled coil to stabilize actin in vivo.
Title: Coiled-coil-mediated dimerization is not required for myosin VI to stabilize actin during spermatid individualization in Drosophila melanogaster.
Genetic characterization of the Drosophila jaguar322 mutant reveals that complete myosin VI loss of function is not lethal.
Title: Genetic characterization of the Drosophila jaguar322 mutant reveals that complete myosin VI loss of function is not lethal.
Miranda protein forms an apical crescent at interphase, but is ubiquitously localized at prophase in a Myosin-II-dependent manner.
Title: Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI.
Data suggest that Echinoid mediates the dimerization of myosin VI/Jaguar in vivo which in turn regulates the reorganization and/or contraction of actin filaments to control changes in cell shape.
Title: Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila.
Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers.
Title: Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis.
MyoVI is required for border cell migration where it stabilizes E-cadherin and Arm.
Title: Myosin VI is required for E-cadherin-mediated border cell migration.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin VI light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament-based movement	NAS Non-traceable Author Statement more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basal protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in basal protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell junction maintenance	TAS Traceable Author Statement more info	PubMed
involved_in dorsal closure	IEP Inferred from Expression Pattern more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion transport along microtubule	IDA Inferred from Direct Assay more info	PubMed
involved_in morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleus localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleus organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudocleavage involved in syncytial blastoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament-based process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin filament-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in investment cone	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
part_of myosin VI complex	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in sperm individualization complex	IDA Inferred from Direct Assay more info	PubMed
part_of unconventional myosin complex	IDA Inferred from Direct Assay more info	PubMed
part_of unconventional myosin complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: jaguar

Names: 95F myosin; 95F unconventional myosin; CG5695-PB; CG5695-PG; CG5695-PH; CG5695-PI; CG5695-PJ; CG5695-PK; CG5695-PL; CG5695-PM; CG5695-PN; jar-PB; jar-PG; jar-PH; jar-PI; jar-PJ; jar-PK; jar-PL; jar-PM; jar-PN; myosin 95F; myosin VI; myosin heavy chain; myosin heavy chain at 95F; myosin-VI; unconventional myosin VI

NP_001014647.2

EC 5.6.1.8

NP_001014648.2

EC 5.6.1.8

NP_001014649.2

EC 5.6.1.8

NP_001014650.2

EC 5.6.1.8

NP_001262905.1

EC 5.6.1.8

NP_001262906.1

EC 5.6.1.8

NP_001287501.1

EC 5.6.1.8

NP_524478.4

EC 5.6.1.8

NP_732976.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24252826..24271233 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079754.4 → NP_524478.4 jaguar, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524478.4

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C6, Q01989, Q59DV3, Q59DV4, Q9VCA4

UniProtKB/TrEMBL

H1UUJ8

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1145 → 1231

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001014650.3 → NP_001014650.2 jaguar, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014650.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGX1

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1160 → 1246

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001275977.2 → NP_001262906.1 jaguar, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262906.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C6, Q01989, Q59DV3, Q59DV4, Q9VCA4

UniProtKB/TrEMBL

H1UUJ8

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1145 → 1231

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_170138.3 → NP_732976.1 jaguar, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732976.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C6, Q01989, Q59DV3, Q59DV4, Q9VCA4

UniProtKB/TrEMBL

H1UUJ8

Related

FBpp0084020

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1145 → 1231

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001275976.1 → NP_001262905.1 jaguar, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262905.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGX1

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1160 → 1246

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001300572.1 → NP_001287501.1 jaguar, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287501.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LHV4

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1130 → 1216

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001014647.3 → NP_001014647.2 jaguar, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014647.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C6, Q01989, Q59DV3, Q59DV4, Q9VCA4

UniProtKB/TrEMBL

H1UUJ8

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1145 → 1231

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001014648.3 → NP_001014648.2 jaguar, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014648.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C6, Q01989, Q59DV3, Q59DV4, Q9VCA4

UniProtKB/TrEMBL

H1UUJ8

Conserved Domains (5) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

pfam16521
Location:1145 → 1231

Myosin-VI_CBD; Myosin VI cargo binding domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001014649.3 → NP_001014649.2 jaguar, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014649.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q01989

Conserved Domains (4) summary

cd01382
Location:71 → 754

MYSc_Myo6; class VI myosin, motor domain

pfam00063
Location:59 → 754

Myosin_head; Myosin head (motor domain)

pfam02736
Location:7 → 45

Myosin_N; Myosin N-terminal SH3-like domain

cl23720
Location:968 → 1015

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)