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beta-PheRS Phenylalanyl-tRNA synthetase, beta-subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42888, updated on 22-Aug-2024

Summary

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Official Symbol
beta-PheRSprovided by FlyBase
Official Full Name
Phenylalanyl-tRNA synthetase, beta-subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0039175
Locus tag
Dmel_CG5706
See related
AllianceGenome:FB:FBgn0039175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5706; Dmel\CG5706
Summary
Enables aminoacyl-tRNA editing activity and phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in embryonic/larval midgut and organism. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See beta-PheRS in Genome Data Viewer
Location:
95F5-95F6; 3-84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24250460..24252679, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20076182..20078401, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45217 Neighboring gene long non-coding RNA:CR44092 Neighboring gene small Cajal body-specific RNA : MeU2-G25 Neighboring gene multiple ankyrin repeats single KH domain Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1 Neighboring gene Organic cation transporter 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic characterization of the Drosophila jaguar322 mutant reveals that complete myosin VI loss of function is not lethal. Morrison JK, et al. Genetics, 2008 May. PMID 18493084, Free PMC Article
  2. Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development. Lu J, et al. Nat Commun, 2014 Nov 27. PMID 25427601, Free PMC Article
  3. A translation-independent function of PheRS activates growth and proliferation in Drosophila. Ho MT, et al. Dis Model Mech, 2021 Mar 18. PMID 33547043, Free PMC Article
  4. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Petritsch C, et al. Dev Cell, 2003 Feb. PMID 12586070
  5. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. Mohr SE, et al. G3 (Bethesda), 2015 Jul 21. PMID 26199285, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of unstable beta-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.
    Title: Effects of unstable β-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.
  2. Knockout of alpha-PheRS (CG2263) and beta-PheRS (CG5706) causes protein mistranslation and affects cellular physiology and development.
    Title: Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phenylalanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phenylalanyl-tRNA synthetase, beta-subunit
Names
CG5706-PA
Phenylalanyl-tRNA synthetase beta subunit
beta-PheRS-PA
NP_651237.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24250460..24252679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142980.4 → NP_651237.1  Phenylalanyl-tRNA synthetase, beta-subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCA5
    Related
    FBpp0084021
    Conserved Domains (4) summary
    smart00873
    Location:118 → 279
    B3_4; B3/4 domain
    PLN02265
    Location:1 → 589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:390 → 588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
    pfam03484
    Location:310 → 372
    B5; tRNA synthetase B5 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCA5.1 Q9VCA5

Gene LinkOut

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Chemical Information
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