FGF4 fibroblast growth factor 4 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: FGF4provided by CGNC
Official Full Name: fibroblast growth factor 4provided by CGNC
Primary source: CGNC:5707
See related: Ensembl:ENSGALG00010025483
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (17143349..17149008, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (17104712..17110369, complement)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the RA pathway acts synergistically with FGF4 in endoderm patterning rather than mediating FGF4 activity
Title: Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis.
Role of FGF4 in cavitation was shown.
Title: Differential regulation of GDF-5 and FGF-2/4 by immobilisation in ovo exposes distinct roles in joint formation.
FGF4 treatment increased phosphorylated MAPK (dpERK) signaling and promoted expression of scleraxis and tenascin in embryonic valves.
Title: BMP and FGF regulatory pathways in semilunar valve precursor cells.
NOGO-A is up-regulated by FGF4 during brain development.
Title: NOGO-A induction and localization during chick brain development indicate a role disparate from neurite outgrowth inhibition.
FGF4-mediated signaling is required for establishing gut tube domains along the A-P axis
Title: FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 4

Names: FGF-4; HBGF-4; fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene); heparin-binding growth factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031546.3 → NP_001026717.3 fibroblast growth factor 4 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/TrEMBL

E1BZW7

Related

ENSGALP00010038439.1, ENSGALT00010062193.1

Conserved Domains (1) summary

pfam00167
Location:70 → 191

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

17143349..17149008 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

17104712..17110369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)