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Mettl3 Methyltransferase like 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42844, updated on 18-Sep-2024

Summary

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Official Symbol
Mettl3provided by FlyBase
Official Full Name
Methyltransferase like 3provided by FlyBase
Primary source
FLYBASE:FBgn0039139
Locus tag
Dmel_CG5933
See related
AllianceGenome:FB:FBgn0039139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5933; dIME4; Dm ime4; Dmel\CG5933; ime4; Ime4; IME4; mettl3; METTL3; Mta70; MTA70
Summary
Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including germarium-derived female germ-line cyst encapsulation; mRNA methylation; and regulation of gene expression. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in embryonic/larval central nervous system; gonad; and ventral neurectoderm. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Mettl3 in Genome Data Viewer
Location:
95D8-95D8; 3-82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24032157..24034257)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19857879..19859979)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Krueppel target at 95D Neighboring gene Like Sm 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene Rox8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitous Knockdown of Mettl3 using TRiP.GL01126 Results in Spermatid Mislocalization During Drosophila Spermatogenesis. Rowe L, et al. MicroPubl Biol, 2022. PMID 35071998, Free PMC Article
  2. Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis. Rockwell AL, et al. Mech Dev, 2020 Dec. PMID 33038528
  3. mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons. Sami JD, et al. Neural Dev, 2022 Oct 15. PMID 36243726, Free PMC Article
  4. N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease. Shafik AM, et al. Genome Biol, 2021 Jan 5. PMID 33402207, Free PMC Article
  5. Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation. Khyzha N, et al. Nat Methods, 2022 Nov. PMID 36192462, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
    Title: Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.
  2. Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.
    Title: Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA m(6)A methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA m(6)A methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA m(6)A methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA m(6)A methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in female sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived female germ-line cyst encapsulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex-chromosome dosage compensation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sex-chromosome dosage compensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
methyltransferase like 3
Names
CG5933-PA
Mettl3-PA
Mta70 homologue
inducer of MEiosis 4 homolog
inducer of meiosis 4
NP_651204.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24032157..24034257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142947.4 → NP_651204.1  methyltransferase like 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCE6
    Related
    FBpp0083917
    Conserved Domains (1) summary
    pfam05063
    Location:407 → 568
    MT-A70; MT-A70
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCE6.1 Q9VCE6

Gene LinkOut

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