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Gba1a Glucocerebrosidase 1a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42796, updated on 2-Nov-2024

Summary

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Official Symbol
Gba1aprovided by FlyBase
Official Full Name
Glucocerebrosidase 1aprovided by FlyBase
Primary source
FLYBASE:FBgn0051148
Locus tag
Dmel_CG31148
See related
AllianceGenome:FB:FBgn0051148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.234; CG10299; CG31148; CT28913; dGba1; dGBA1a; Dmel\CG31148; GBA; gba1; GBA1a
Summary
Enables glucosylceramidase activity. Involved in several processes, including adult locomotory behavior; cellular response to unfolded protein; and determination of adult lifespan. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Gba1a in Genome Data Viewer
Location:
95A8-95A8; 3-80 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23700621..23702605)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19526343..19528327)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene portabella Neighboring gene uncharacterized protein Neighboring gene Quiescin sulfhydryl oxidase 4 Neighboring gene Glucocerebrosidase 1b Neighboring gene antisense RNA:CR44052

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucocerebrosidase Mutations in Parkinson Disease. O'Regan G, et al. J Parkinsons Dis, 2017. PMID 28598856
  2. The contribution of mutant GBA to the development of Parkinson disease in Drosophila. Maor G, et al. Hum Mol Genet, 2016 Jul 1. PMID 27162249, Free PMC Article
  3. Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease. Atilano ML, et al. PLoS Genet, 2023 Dec. PMID 38127816, Free PMC Article
  4. Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut. Dasari SK, et al. Cell Cycle, 2017. PMID 28933588, Free PMC Article
  5. Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles. Jewett KA, et al. PLoS Genet, 2021 Feb. PMID 33539341, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Uncovered Function of the Drosophila GBA1a-Encoded Protein.
    Title: The Uncovered Function of the Drosophila GBA1a-Encoded Protein.
  2. Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles.
    Title: Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles.
  3. Minos insertion mutant glucocerebrosidase 1a CG31148 and its RNAi line did not show severe phenotype as observed in glucocerebrosidase 1b CG31414 gene mutation, suggesting that CG31414 gene mutation might be useful for unraveling the molecular mechanism of Gaucher's disease.
    Title: Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glucosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucosylceramidase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to unfolded protein IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glucosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucocerebrosidase 1a
Names
CG31148-PA
Gba1a-PA
glucosylceramidase
NP_651172.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23700621..23702605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142915.3 → NP_651172.1  glucocerebrosidase 1a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SL4, Q9VCJ4
    Related
    FBpp0083833
    Conserved Domains (1) summary
    cl23815
    Location:29 → 558
    Glyco_hydro_30; O-Glycosyl hydrolase family 30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCJ4 Q9VCJ4

Gene LinkOut

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