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Usp12-46 Ubiquitin-specific protease 12/46 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42702, updated on 2-Nov-2024

Summary

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Official Symbol
Usp12-46provided by FlyBase
Official Full Name
Ubiquitin-specific protease 12/46provided by FlyBase
Primary source
FLYBASE:FBgn0039025
Locus tag
Dmel_CG7023
See related
AllianceGenome:FB:FBgn0039025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7023; Dmel\CG7023; Q9VCT9; Usp12; Usp12/46
Summary
Enables deubiquitinase activity. Involved in negative regulation of Notch signaling pathway; negative regulation of ubiquitin-dependent protein catabolic process; and positive regulation of canonical Wnt signaling pathway. Part of peptidase complex. Is expressed in several structures, including embryonic/larval midgut interstitial cell; ganglia; gut section; and salivary gland body primordium. Orthologous to several human genes including USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Usp12-46 in Genome Data Viewer
Location:
94C4-94C6; 3-76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22750901..22776374)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18576623..18602096)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1c Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13 Neighboring gene Neprilysin-like 14 Neighboring gene Neprilysin-like 15 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43654 Neighboring gene mir-4953 stem loop Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Aron R, et al. Nat Commun, 2018 Sep 28. PMID 30266909, Free PMC Article
  2. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. Jacomin AC, et al. PLoS One, 2015. PMID 26571504, Free PMC Article
  3. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Spencer ZT, et al. Nat Commun, 2023 Oct 5. PMID 37798281, Free PMC Article
  4. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. Moretti J, et al. J Biol Chem, 2012 Aug 24. PMID 22778262, Free PMC Article
  5. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Acar M, et al. Cell, 2008 Jan 25. PMID 18243100, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Ubiquitin-specific protease 12/46
Names
CG7023-PB
Ubiquitin-specific protease 12/46 ortholog
Usp12-46-PB
NP_651099.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22750901..22776374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142842.3 → NP_651099.1  Ubiquitin-specific protease 12/46 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCT9
    Related
    FBpp0083704
    Conserved Domains (1) summary
    cd02663
    Location:25 → 419
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCT9 Q9VCT9

Gene LinkOut

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