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btn buttonless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42664, updated on 2-Nov-2024

Summary

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Official Symbol
btnprovided by FlyBase
Official Full Name
buttonlessprovided by FlyBase
Primary source
FLYBASE:FBgn0014949
Locus tag
Dmel_CG5264
See related
AllianceGenome:FB:FBgn0014949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1261/13; BTN; btn/MEOX; CG5264; Dmel\CG5264
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic ventral epidermis; larval foregut atrium; and larval thoracic perisympathetic organ. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to several human genes including MEOX2 (mesenchyme homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See btn in Genome Data Viewer
Location:
94B5-94B5; 3-75 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22586149..22586625, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18411871..18412347, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 6 Neighboring gene uncharacterized protein Neighboring gene Diphthamide methyltransferase Neighboring gene uncharacterized protein Neighboring gene Exchange factor for Arf 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. Chiang C, et al. Development, 1994 Dec. PMID 7821224
  2. CNS midline to mesoderm signaling in Drosophila. Zhou L, et al. Mech Dev, 1997 Sep. PMID 9347915
  3. Induction of identified mesodermal cells by CNS midline progenitors in Drosophila. Lüer K, et al. Development, 1997 Jul. PMID 9226439
  4. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Zhang YQ, et al. Gene, 1999 Jun 11. PMID 10375633
  5. Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila. Yin Z, et al. Dev Genet, 1998. PMID 9621427

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
buttonless
Names
CG5264-PA
btn-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22586149..22586625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170026.2 → NP_732768.1  buttonless [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732768.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0IGT7, Q9VCY0
    Related
    FBpp0083671
    Conserved Domains (1) summary
    pfam00046
    Location:90 → 142
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U984 Q9U984
Q9VCY0 Q9VCY0

Gene LinkOut

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