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Dph5 Diphthamide methyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42663, updated on 2-Nov-2024

Summary

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Official Symbol
Dph5provided by FlyBase
Official Full Name
Diphthamide methyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0024558
Locus tag
Dmel_CG31289
See related
AllianceGenome:FB:FBgn0024558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA.LD12153; BcDNA:LD12153; CG31289; CG5275; Dmel\CG31289; l(3)L4910
Summary
Predicted to enable diphthine methyl ester synthase activity. Involved in positive regulation of translation. Predicted to be located in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; embryonic anal pad; embryonic/larval midgut primordium; germline cell; and gut section. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Orthologous to human DPH5 (diphthamide biosynthesis 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Dph5 in Genome Data Viewer
Location:
94B5-94B5; 3-75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22582028..22583225, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18407750..18408947, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene stuck in traffic Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene buttonless

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diphthamide modification of eEF2 is required for gut tumor-like hyperplasia induced by oncogenic Ras. Tsuda-Sakurai K, et al. Genes Cells, 2020 Feb. PMID 31828897
  2. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Zhang YQ, et al. Gene, 1999 Jun 11. PMID 10375633
  3. Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine. Obata F, et al. Dev Cell, 2018 Mar 26. PMID 29587144
  4. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
  5. Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. Varma P, et al. J Biosci, 2011 Aug. PMID 21799256

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables diphthine methyl ester synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  
involved_in protein histidyl modification to diphthamide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
diphthamide methyltransferase
Names
CG31289-PA
Dph5-PA
NP_524452.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22582028..22583225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079728.5 → NP_524452.4  diphthamide methyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524452.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IN02
    Related
    FBpp0083673
    Conserved Domains (1) summary
    PTZ00175
    Location:1 → 270
    PTZ00175; diphthine synthase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IN02 Q8IN02

Gene LinkOut

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