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SKIP Shal K[+] channel interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42601, updated on 18-Sep-2024

Summary

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Official Symbol
SKIPprovided by FlyBase
Official Full Name
Shal K[+] channel interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051163
Locus tag
Dmel_CG31163
See related
AllianceGenome:FB:FBgn0051163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13863; CG13864; CG31163; CG5736; CG7086; CG7087; Dmel\CG31163
Summary
Involved in sensory perception of smell. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; inclusive hindgut primordium; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to several human genes including SASH3 (SAM and SH3 domain containing 3) and SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See SKIP in Genome Data Viewer
Location:
94A2-94A4; 3-74 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22133830..22296126)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17959552..18121848)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 94c Neighboring gene long non-coding RNA:CR45224 Neighboring gene GLD2 poly(A) polymerase Neighboring gene mir-1010 stem loop Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of subcellular dendritic synapse specificity by axon guidance cues. Sales EC, et al. Elife, 2019 Apr 23. PMID 31012844, Free PMC Article
  2. The mirtron miR-1010 functions in concert with its host gene SKIP to balance elevation of nAcRβ2. Amourda C, et al. Sci Rep, 2020 Feb 3. PMID 32015391, Free PMC Article
  3. The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway. Contreras-Cornejo H, et al. Cell Div, 2016. PMID 27708688, Free PMC Article
  4. Fast inactivation of Shal (K(v)4) K+ channels is regulated by the novel interactor SKIP3 in Drosophila neurons. Diao F, et al. Mol Cell Neurosci, 2009 Sep. PMID 19463952, Free PMC Article
  5. High rate of recent transposable element-induced adaptation in Drosophila melanogaster. González J, et al. PLoS Biol, 2008 Oct 21. PMID 18942889, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in regulation of intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
shal K[+] channel interacting protein
Names
CG31163-PB
CG31163-PE
CG31163-PF
CG31163-PG
CG31163-PH
CG31163-PI
CG31163-PJ
SKIP-PB
SKIP-PE
SKIP-PF
SKIP-PG
SKIP-PH
SKIP-PI
SKIP-PJ
skal K[+] channel interacting protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22133830..22296126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260304.2 → NP_001247233.1  shal K[+] channel interacting protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247233.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI30
    Conserved Domains (4) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:850 → 913
    SAM; Sterile alpha motif
    cl15755
    Location:854 → 912
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17036
    Location:769 → 822
    SH3; Src Homology 3 domain superfamily

  2. NM_001275899.1 → NP_001262828.1  shal K[+] channel interacting protein, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHM3
    Conserved Domains (4) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:813 → 876
    SAM; Sterile alpha motif
    cl15755
    Location:817 → 875
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17036
    Location:732 → 785
    SH3; Src Homology 3 domain superfamily

  3. NM_001260305.1 → NP_001247234.1  shal K[+] channel interacting protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6C1
    Conserved Domains (4) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:813 → 876
    SAM; Sterile alpha motif
    cl15755
    Location:817 → 875
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17036
    Location:732 → 785
    SH3; Src Homology 3 domain superfamily

  4. NM_001043277.3 → NP_001036742.2  shal K[+] channel interacting protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036742.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI30
    Conserved Domains (4) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:850 → 913
    SAM; Sterile alpha motif
    cl15755
    Location:854 → 912
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17036
    Location:769 → 822
    SH3; Src Homology 3 domain superfamily

  5. NM_169997.5 → NP_732703.1  shal K[+] channel interacting protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732703.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZS0, Q8T9B0
    Related
    FBpp0083595
    Conserved Domains (4) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:738 → 801
    SAM; Sterile alpha motif
    cl15755
    Location:742 → 800
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17036
    Location:657 → 710
    SH3; Src Homology 3 domain superfamily

  6. NM_001275898.1 → NP_001262827.1  shal K[+] channel interacting protein, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHV7
    Conserved Domains (4) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:738 → 801
    SAM; Sterile alpha motif
    cl15755
    Location:742 → 800
    SAM_superfamily; SAM (Sterile alpha motif )
    cl17036
    Location:657 → 710
    SH3; Src Homology 3 domain superfamily

  7. NM_001275897.1 → NP_001262826.1  shal K[+] channel interacting protein, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262826.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH49
    Conserved Domains (2) summary
    cd09527
    Location:4 → 65
    SAM_Samd5; SAM domain of Samd5 subfamily
    smart00454
    Location:7 → 65
    SAM; Sterile alpha motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6C1 A0A0B4K6C1
A0A0B4KH49 A0A0B4KH49
A0A0B4KHM3 A0A0B4KHM3
A0A0B4KHV7 A0A0B4KHV7
Q0KI30 Q0KI30
Q8SZS0 Q8SZS0
Q8T9B0 Q8T9B0
Q95RX2 Q95RX2

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