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Mitofilin mitofilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42587, updated on 2-Nov-2024

Summary

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Official Symbol
Mitofilinprovided by FlyBase
Official Full Name
mitofilinprovided by FlyBase
Primary source
FLYBASE:FBgn0019960
Locus tag
Dmel_CG6455
See related
AllianceGenome:FB:FBgn0019960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A0A0B4KGN2; CG 6455; CG6455; dIMMT; Dmel\CG6455; dMic60; dMIC60; MIC60; mitofilin
Summary
Enables ATP-dependent protein binding activity and protein kinase binding activity. Involved in mitochondrion organization. Located in mitochondrion. Part of MICOS complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Mitofilin in Genome Data Viewer
Location:
94A1-94A1; 3-74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22019505..22023335, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17845227..17849057, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Testicular haploid expressed gene Neighboring gene Isocitrate dehydrogenase 3b Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene uncharacterized protein Neighboring gene Cytochrome c heme lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure. Tsai PI, et al. Mol Biol Cell, 2017 Nov 15. PMID 28904209, Free PMC Article
  2. Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture. Graham LC, et al. Mol Neurodegener, 2017 Oct 27. PMID 29078798, Free PMC Article
  3. Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. Benincá C, et al. J Med Genet, 2021 Mar. PMID 32439808, Free PMC Article
  4. Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue. Wang LJ, et al. Biol Open, 2020 Dec 2. PMID 33268479, Free PMC Article
  5. Drosophila MIC10b can polymerize into cristae-shaping filaments. Stephan T, et al. Life Sci Alliance, 2024 Apr. PMID 38253420, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitofilin
Names
CG6455-PC
CG6455-PD
CG6455-PE
MICOS complex subunit MIC60
Mitofilin-PC
Mitofilin-PD
Mitofilin-PE
Motor-protein
dmitofilin
motor protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22019505..22023335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079720.3 → NP_524444.3  mitofilin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524444.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91928, Q8IN13, Q9V3K0
    UniProtKB/TrEMBL
    A0A0B4KHL7
    Conserved Domains (1) summary
    pfam09731
    Location:68 → 732
    Mitofilin; Mitochondrial inner membrane protein

  2. NM_001275889.1 → NP_001262818.1  mitofilin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262818.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91928, Q8IN13, Q9V3K0
    UniProtKB/TrEMBL
    A0A0B4KHL7
    Conserved Domains (1) summary
    pfam09731
    Location:68 → 732
    Mitofilin; Mitochondrial inner membrane protein

  3. NM_001275890.1 → NP_001262819.1  mitofilin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGN2
    Conserved Domains (1) summary
    pfam09731
    Location:68 → 739
    Mitofilin; Mitochondrial inner membrane protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGN2 A0A0B4KGN2
A0A0B4KHL7 A0A0B4KHL7
P91928.4 P91928

Gene LinkOut

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