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GABA-B-R2 metabotropic GABA-B receptor subtype 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42561, updated on 2-Nov-2024

Summary

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Official Symbol
GABA-B-R2provided by FlyBase
Official Full Name
metabotropic GABA-B receptor subtype 2provided by FlyBase
Primary source
FLYBASE:FBgn0027575
Locus tag
Dmel_CG6706
See related
AllianceGenome:FB:FBgn0027575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
:GABA-B-R2; anon-WO0170980.58; anon-WO0170980.59; BcDNA:GH07312; CG6706; D-GABA-B-R2; D-Gaba2; D-GABA[[B]]R2; dGB2; Dmel\CG6706; GABA B R2; GABA-BR2; GABA-[[B]]R2; GABA2; GABAB(R2); GABAB-R2; GABABR-R2; GABABR2; GABA[[B]]-R2; GABA[[B]]R2; GB2; GBR; GH07312
Summary
Enables G protein-coupled GABA receptor activity and protein heterodimerization activity. Involved in several processes, including cellular response to mechanical stimulus; gamma-aminobutyric acid signaling pathway; and negative regulation of secretion by cell. Located in plasma membrane. Part of G protein-coupled receptor heterodimeric complex. Is expressed in several structures, including ellipsoid body layer; ganglia; optic lobe centrifugal columnar neurons; organism subdivision; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See GABA-B-R2 in Genome Data Viewer
Location:
93F9-93F9; 3-73 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21770333..21775840, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17596055..17601562, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bursicon Neighboring gene uncharacterized protein Neighboring gene RNA polymerase I subunit H Neighboring gene torso-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GABA(B) receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster. Gmeiner F, et al. J Exp Biol, 2013 Oct 15. PMID 24068350
  2. Presynaptic gain control drives sweet and bitter taste integration in Drosophila. Chu B, et al. Curr Biol, 2014 Sep 8. PMID 25131672
  3. Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. Martelli C, et al. Elife, 2019 Jun 10. PMID 31169499, Free PMC Article
  4. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Dzitoyeva S, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12692303, Free PMC Article
  5. GABAergic lateral interactions tune the early stages of visual processing in Drosophila. Freifeld L, et al. Neuron, 2013 Jun 19. PMID 23791198, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled GABA receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled GABA receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled GABA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in olfactory behavior IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of G protein-coupled receptor heterodimeric complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of G protein-coupled receptor heterodimeric complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metabotropic GABA-B receptor subtype 2
Names
CG6706-PA
CG6706-PB
CG6706-PC
GABA-B-R2-PA
GABA-B-R2-PB
GABA-B-R2-PC
GABA[[B]]- 2 receptor
GABA[[B]]receptor2
metabotropic GABA[[B]] receptor 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21770333..21775840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169968.1 → NP_732658.1  metabotropic GABA-B receptor subtype 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IN24, Q9BML6
    Related
    FBpp0083565, FBtr0084167
    Conserved Domains (3) summary
    cd06366
    Location:32 → 418
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:459 → 710
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:52 → 396
    ANF_receptor; Receptor family ligand binding region

  2. NM_079714.2 → NP_524438.1  metabotropic GABA-B receptor subtype 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524438.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BML6, Q9Y133
    Related
    FBpp0083566, FBtr0084168
    Conserved Domains (3) summary
    cd06366
    Location:32 → 418
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:459 → 710
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:52 → 396
    ANF_receptor; Receptor family ligand binding region

  3. NM_001300527.1 → NP_001287456.1  metabotropic GABA-B receptor subtype 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287456.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHR4, Q9BML6
    Conserved Domains (3) summary
    cd06366
    Location:32 → 418
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:459 → 712
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:52 → 396
    ANF_receptor; Receptor family ligand binding region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHR4 A0A0B4LHR4
Q8IN24 Q8IN24
Q9BML6 Q9BML6
Q9Y133 Q9Y133

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