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Ugt49B2 UDP-glycosyltransferase family 49 member B2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42538, updated on 18-Sep-2024

Summary

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Official Symbol
Ugt49B2provided by FlyBase
Official Full Name
UDP-glycosyltransferase family 49 member B2provided by FlyBase
Primary source
FLYBASE:FBgn0038886
Locus tag
Dmel_CG6475
See related
AllianceGenome:FB:FBgn0038886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6475; Dmel\CG6475; UGT49B2
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; and female reproductive organ cancer (multiple). Orthologous to several human genes including UGT1A1 (UDP glucuronosyltransferase family 1 member A1); UGT1A10 (UDP glucuronosyltransferase family 1 member A10); and UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ugt49B2 in Genome Data Viewer
Location:
93D10-93D10; 3-71 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21397781..21399742, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17223503..17225464, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tinman Neighboring gene bagpipe Neighboring gene long non-coding RNA:CR46046 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis. Ahn SJ, et al. Front Physiol, 2021. PMID 33815151, Free PMC Article
  2. Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster. Huylmans AK, et al. G3 (Bethesda), 2014 Sep 22. PMID 25246242, Free PMC Article
  3. Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. Coelho A, et al. PLoS One, 2015. PMID 25671424, Free PMC Article
  4. Functional and phylogenetic analyses of a putative Drosophila melanogaster UDP-glycosyltransferase gene. Luque T, et al. Insect Biochem Mol Biol, 2002 Dec. PMID 12429111
  5. A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells. Ferjoux G, et al. Dev Biol, 2007 May 15. PMID 17418114

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glycosyltransferase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycosylation ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
UDP-glycosyltransferase family 49 member B2
Names
CG6475-PD
Ugt49B2-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21397781..21399742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104389.3 → NP_001097859.4  UDP-glycosyltransferase family 49 member B2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097859.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDA5
    Conserved Domains (2) summary
    PHA03392
    Location:1 → 502
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:31 → 497
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDA5 Q9VDA5

Gene LinkOut

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