Rab1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab1provided by FlyBase
Primary source: FLYBASE:FBgn0285937
Locus tag: Dmel_CG3320
See related: AllianceGenome:FB:FBgn0285937
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF55873; CG3320; dar6; Dar6; Dm Rab1; Dmel\CG3320; DmRab1; drab1; dRab1; DRab1; DRAB1; O18332; omt; rab1; Rab1a; RAB1a
Summary: Enables GTPase activity and Golgi transport complex binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; positive regulation of cellular component organization; and positive regulation of insulin secretion. Located in Golgi apparatus; cleavage furrow; and endoplasmic reticulum exit site. Is expressed in several structures, including adult insulin secreting cell of pars intercerebralis; central nervous system; embryonic/larval optic stalk sheath cell; imaginal disc; and photoreceptor. Orthologous to several human genes including RAB1A (RAB1A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 93D2-93D2; 3-71 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21266029..21269060, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17091751..17094782, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel function for Rab1 and Rab11 during secretory granule maturation.
Title: A novel function for Rab1 and Rab11 during secretory granule maturation.
It has been demonstrated that the COG complex cooperates with Rab1 and GOLPH3 to regulate Golgi trafficking, and that overexpression of Rab1 can rescue the cytokinesis and locomotor defects associated with loss of Cog7.
Title: COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.
Drosophila Tempura, a novel protein prenyltransferase alpha subunit, regulates notch signaling via Rab1 and Rab11.
Title: Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.
Results suggest a novel function for Rab1a in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway.
Title: Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables Golgi transport complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral entry into host cell	HMP more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cleavage furrow	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab1

Names: CG3320-PA; Rab-protein 1; Rab1-PA; dendritic arbor reduction 6; omelette

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21266029..21269060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169953.3 → NP_732610.1 Rab1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732610.1

Status: REVIEWED

UniProtKB/TrEMBL

O18332

Related

FBpp0083503

Conserved Domains (1) summary

cd01869
Location:10 → 175

Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1