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RhoGAP93B Rho GTPase activating protein at 93B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42496, updated on 2-Nov-2024

Summary

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Official Symbol
RhoGAP93Bprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 93Bprovided by FlyBase
Primary source
FLYBASE:FBgn0038853
Locus tag
Dmel_CG3421
See related
AllianceGenome:FB:FBgn0038853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3421; CrGAP; Dmel\CG3421; RhoGAP; rhoGAP93B; vilse; Vilse
Summary
Enables GTPase activator activity. Involved in axon midline choice point recognition. Located in cytoplasm. Is expressed in adult fat body; adult head; and leg. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See RhoGAP93B in Genome Data Viewer
Location:
93B10-93B11; 3-70 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21083043..21097827, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16908765..16923549, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene doublesex-Mab related 93B Neighboring gene Hematopoietically expressed homeobox Neighboring gene long non-coding RNA:CR44178 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46045 Neighboring gene TBC1 domain family member 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. Yang L, et al. Neuron, 2006 Nov 22. PMID 17114045
  2. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Lundström A, et al. Genes Dev, 2004 Sep 1. PMID 15342493, Free PMC Article
  3. Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling. Morin-Poulard I, et al. Nat Commun, 2016 May 19. PMID 27193394, Free PMC Article
  4. Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division. de Torres-Jurado A, et al. Curr Biol, 2022 May 23. PMID 35472309
  5. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon midline choice point recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 93B
Names
CG3421-PA
RhoGAP93B-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21083043..21097827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142682.2 → NP_650939.2  Rho GTPase activating protein at 93B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650939.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P77, Q9VDE9
    Related
    FBpp0083438
    Conserved Domains (3) summary
    cd04389
    Location:1133 → 1320
    RhoGAP_KIAA1688; RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into ...
    pfam00397
    Location:50 → 75
    WW; WW domain
    cl02480
    Location:956 → 1122
    MyTH4; MyTH4 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YU00 Q7YU00
Q86P77 Q86P77
Q9VDE9 Q9VDE9

Gene LinkOut

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