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Rlip Ral interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42484, updated on 2-Nov-2024

Summary

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Official Symbol
Rlipprovided by FlyBase
Official Full Name
Ral interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0026056
Locus tag
Dmel_CG11622
See related
AllianceGenome:FB:FBgn0026056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11622; D-RLIP; Dmel\CG11622; dRalBP; dRlip; dRLIP; DRLIP; RalBP1; RhoGAP-93B3; RLIP; RLIP1
Summary
Enables small GTPase binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Rlip in Genome Data Viewer
Location:
93B4-93B4; 3-70 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21017684..21020753)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16843406..16846475)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Na/Ca-exchange protein Neighboring gene Alkaline phosphatase 5 Neighboring gene uncharacterized protein Neighboring gene pegasus Neighboring gene Dynein heavy chain at 93AB

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and expression of Ima, a novel Ral-interacting Drosophila protein. Beller M, et al. Mech Dev, 2002 Dec. PMID 14516694
  2. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. Jullien-Flores V, et al. J Cell Sci, 2000 Aug. PMID 10910768
  3. RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Johansson J, et al. Cell Stem Cell, 2019 Apr 4. PMID 30853556, Free PMC Article
  4. Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42. Blanke S, et al. FASEB J, 2006 Apr. PMID 16581976
  5. RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. Rossé C, et al. J Biol Chem, 2003 Aug 15. PMID 12775724

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Ras protein signal transduction IC
Inferred by Curator
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Ral interacting protein
Names
CG11622-PA
CG11622-PB
Rlip-PA
Rlip-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21017684..21020753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142676.4 → NP_650933.2  Ral interacting protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650933.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96392, Q8MZ58, Q9VDG2
    Related
    FBpp0083406
    Conserved Domains (1) summary
    cd04381
    Location:187 → 368
    RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...

  2. NM_001275863.1 → NP_001262792.1  Ral interacting protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHU1
    Conserved Domains (1) summary
    cd04381
    Location:186 → 367
    RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHU1 A0A0B4KHU1
Q9VDG2.1 Q9VDG2

Gene LinkOut

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