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Adss Adenylosuccinate synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42466, updated on 2-Nov-2024

Summary

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Official Symbol
Adssprovided by FlyBase
Official Full Name
Adenylosuccinate synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027493
Locus tag
Dmel_CG17273
See related
AllianceGenome:FB:FBgn0027493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AdSS; BcDNA:LD32788; CG17273; Dmel\CG17273; PURA_DROME
Summary
Predicted to enable adenylosuccinate synthase activity. Predicted to be involved in 'de novo' AMP biosynthetic process and IMP metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Adss in Genome Data Viewer
Location:
93A1-93A1; 3-69 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20824667..20830580, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16650389..16656302, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S20 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44047 Neighboring gene uncharacterized protein Neighboring gene Syndapin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
  2. Chromosomal instability causes sensitivity to protein folding stress and ATP depletion. Khan M, et al. Biol Open, 2018 Oct 16. PMID 30327366, Free PMC Article
  3. Phylogeny and evolution of mycophagy in the Zygothrica genus group (Diptera: Drosophilidae). Zhang Y, et al. Mol Phylogenet Evol, 2021 Oct. PMID 34252547
  4. PINK1 and Parkin regulate IP(3)R-mediated ER calcium release. Ham SJ, et al. Nat Commun, 2023 Aug 25. PMID 37626046, Free PMC Article
  5. A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Morin X, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742088, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylosuccinate synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenylosuccinate synthetase
Names
Adss-PA
CG17273-PA
NP_650918.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20824667..20830580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142661.3 → NP_650918.1  adenylosuccinate synthetase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MZ11, Q9VDI2, Q9Y0Y2
    Related
    FBpp0083395
    Conserved Domains (1) summary
    pfam00709
    Location:28 → 444
    Adenylsucc_synt; Adenylosuccinate synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y0Y2.1 Q9Y0Y2

Gene LinkOut

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