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Oct-TyrR Octopamine-Tyramine receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42452, updated on 19-Jun-2024

Summary

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Official Symbol
Oct-TyrRprovided by FlyBase
Official Full Name
Octopamine-Tyramine receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0004514
Locus tag
Dmel_CG7485
See related
AllianceGenome:FB:FBgn0004514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7485; Dmel\CG7485; Dmoct/tyr; DmTAR1; DmTyrR; DrmOTR; hono; l(3)neo30; OA-R; OAR_DROME; Ocr; OcR; Oct/Tyr; OctoR1; OctyR99AB; OTR; tar1; TAR1; Tyr; TyR; TYR; Tyr-dro; Tyr-OctR; TyrR
Summary
Enables G protein-coupled amine receptor activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; and sensory perception of smell. Is integral component of plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval aorta; embryonic/larval nervous system; epithelial tube; and gut. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Oct-TyrR in Genome Data Viewer
Location:
79B1-79B2; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22035003..22065279)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22028103..22058379)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44687 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Monoterpenes alter TAR1-driven physiology in Drosophila species. Finetti L, et al. J Exp Biol, 2021 Jan 7. PMID 33234680
  2. Modulation of Drosophila suzukii type 1 tyramine receptor (DsTAR1) by monoterpenes: a potential new target for next generation biopesticides. Finetti L, et al. Pestic Biochem Physiol, 2020 May. PMID 32359540
  3. A new method of recording from the giant fiber of Drosophila melanogaster shows that the strength of its auditory inputs remains constant with age. Blagburn JM. PLoS One, 2020. PMID 31910219, Free PMC Article
  4. Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils. Enan EE. Insect Biochem Mol Biol, 2005 Apr. PMID 15763467
  5. Regulation of chloride permeability by endogenously produced tyramine in the Drosophila Malpighian tubule. Blumenthal EM. Am J Physiol Cell Physiol, 2003 Mar. PMID 12444020

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Monoterpenes alter TAR1-driven physiology in Drosophila species.
    Title: Monoterpenes alter TAR1-driven physiology in Drosophila species.
  2. We show that tyramine is released into the CNS to reduce motoneuron intrinsic excitability and responses to excitatory cholinergic input, both by tyramine(honoka) receptor activation and by downstream decrease of L-type calcium current
    Title: Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state.
  3. results uncover a tiny population of male-specific octopamine(oa) receptor neurons that mediate a specific influence of OA on aggression, independent of any effect on arousal.
    Title: A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila.
  4. Site-directed mutagenesis studies show that the receptor binds various amino acids.
    Title: Site-directed mutagenesis studies on the Drosophila octopamine/tyramine receptor.
  5. Correlatoin between cellular changes and insecticidal activity of tested plant essential oils, and suggests that the toxicity of at least two of these chemicals is mediated through the tyramine receptor.
    Title: Molecular response of Drosophila melanogaster tyramine receptor cascade to plant essential oils.
Submit: New GeneRIF Correction

General gene information

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Homology

mobile_element

  • Loc: 22063188-22063510 mobile_element_type = transposon:INE-1{}2169

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled amine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables octopamine receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in octopamine or tyramine signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in octopamine or tyramine signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Octopamine-Tyramine receptor
Names
CG7485-PA
CG7485-PB
Oct-TyrR-PA
Oct-TyrR-PB
Oct/Tyr receptor
Tyramine-receptor
honoka
octopamine receptor
octopamine receptor 1
octopamine/tyramine receptor
tyramine receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22035003..22065279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079695.4 → NP_524419.2  Octopamine-Tyramine receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524419.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22270, Q1RKQ4, Q95YF4, Q9VNW3
    UniProtKB/TrEMBL
    E1JI27
    Related
    FBpp0078132
    Conserved Domains (2) summary
    pfam00001
    Location:126 → 293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl14876
    Location:113 → 244
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. NM_001170023.2 → NP_001163494.1  Octopamine-Tyramine receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163494.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22270, Q1RKQ4, Q95YF4, Q9VNW3
    UniProtKB/TrEMBL
    E1JI27
    Conserved Domains (2) summary
    pfam00001
    Location:126 → 293
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl14876
    Location:113 → 244
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JI27 E1JI27
P22270.2 P22270

Gene LinkOut

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