Septin2 Septin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Septin2provided by FlyBase
Official Full Name: Septin 2provided by FlyBase
Primary source: FLYBASE:FBgn0014029
Locus tag: Dmel_CG4173
See related: AllianceGenome:FB:FBgn0014029
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38961; CG4173; Dmel\CG4173; DSep2; dSEPT2; sep2; Sep2
Summary: Enables GTPase activity and protein homodimerization activity. Involved in growth of a germarium-derived egg chamber; imaginal disc development; and regulation of cell cycle. Part of septin complex. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; germ layer; presumptive embryonic/larval system; and stage 5 embryo. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including SEPTIN11 (septin 11) and SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20586129..20588356, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16411851..16414078, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellularization	TAS Traceable Author Statement more info	PubMed
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth of a germarium-derived egg chamber	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info

Names: CG4173-PA; CG4173-PB; Septin2-PA; Septin2-PB; septin; septin-2; septin2

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