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Tmlh Trimethyllysine hydroxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42421, updated on 2-Nov-2024

Summary

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Official Symbol
Tmlhprovided by FlyBase
Official Full Name
Trimethyllysine hydroxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038795
Locus tag
Dmel_CG4335
See related
AllianceGenome:FB:FBgn0038795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4335; Dmel\CG4335; TMLH; TMLHE
Summary
Predicted to enable trimethyllysine dioxygenase activity. Predicted to be involved in carnitine biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TMLHE (trimethyllysine hydroxylase, epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Tmlh in Genome Data Viewer
Location:
92E7-92E7; 3-68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20406615..20407871, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16232337..16233593, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45023 Neighboring gene Metallothionein C Neighboring gene Glial cell line-derived neurotrophic family receptor-like Neighboring gene eukaryotic translation initiation factor 3 subunit g2 Neighboring gene long non-coding RNA:CR44400

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII. Kallijärvi J, et al. PLoS One, 2012. PMID 23284846, Free PMC Article
  2. Oncogenic stress-induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila. Okada M, et al. EMBO J, 2023 Jun 15. PMID 37140455, Free PMC Article
  3. L-Carnitine in Drosophila: A Review. Carillo MR, et al. Antioxidants (Basel), 2020 Dec 21. PMID 33371457, Free PMC Article
  4. A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Egli D, et al. Mol Cell Biol, 2006 Mar. PMID 16508004, Free PMC Article
  5. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables trimethyllysine dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables trimethyllysine dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carnitine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnitine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
trimethyllysine hydroxylase
Names
CG4335-PA
TML hydroxylase
Tmlh-PA
NP_650886.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20406615..20407871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142629.4 → NP_650886.1  trimethyllysine hydroxylase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650886.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V6C2, Q9VDM7
    Related
    FBpp0083302
    Conserved Domains (3) summary
    TIGR02410
    Location:19 → 361
    carnitine_TMLD; trimethyllysine dioxygenase
    cl00184
    Location:110 → 350
    CAS_like; Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases ...
    cl01414
    Location:19 → 70
    DUF971; Protein of unknown function (DUF971)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDM7 Q9VDM7

Gene LinkOut

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