Hs6st Heparan sulfate 6-O-sulfotransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hs6stprovided by FlyBase
Official Full Name: Heparan sulfate 6-O-sulfotransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0038755
Locus tag: Dmel_CG4451
See related: AllianceGenome:FB:FBgn0038755
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11683; CG17188; CG18533; CG4451; dHS6ST; Dmel\CG4451; DmHs6st; hs6st; HS6ST
Summary: Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in several processes, including heparan sulfate proteoglycan biosynthetic process; imaginal disc-derived wing margin morphogenesis; and regulation of imaginal disc growth. Predicted to be located in membrane. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; dorsal pharyngeal muscle cell; embryonic/larval dorsal vessel; and tracheal primordium. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to several human genes including HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 92B8-92C1; 3-67 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19929277..20008512, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15754999..15834234, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sulfation compensation depends on the coordinated activities of Hs2st, Hs6st, and Sulf1.
Title: The role of Drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation.
We found that mutations in Hs2st or Hs6st had unexpectedly little effect on tracheal morphogenesis. Structural analysis of mutant HS revealed not only a loss of corresponding sulfation, but also a compensatory increase of sulfation at other positions.
Title: Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1680 (e-PCR)
- UniSTS:62824

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c20001838-20001699 mobile_element_type = transposon:FB{}4816

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables heparan sulfate 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparan sulfate 6-O-sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heparan sulfate 6-O-sulfotransferase

Names: 6-O sulfotransferase; 6-O-sulfotransferase; CG4451-PA; CG4451-PB; HS 6-O-sulfotransferase; Hs6st-PA; Hs6st-PB

NP_001262750.1

EC 2.8.2.-

NP_524409.2

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

19929277..20008512 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275821.1 → NP_001262750.1 heparan sulfate 6-O-sulfotransferase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262750.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960R4, Q968Z7, Q9VDR6

Conserved Domains (1) summary

pfam03567
Location:144 → 410

Sulfotransfer_2; Sulfotransferase family
NM_079685.3 → NP_524409.2 heparan sulfate 6-O-sulfotransferase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524409.2

Status: REVIEWED

UniProtKB/TrEMBL

Q960R4, Q968Z7, Q9VDR6

Related

FBpp0083255

Conserved Domains (1) summary

pfam03567
Location:144 → 410

Sulfotransfer_2; Sulfotransferase family