Delta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Deltaprovided by FlyBase
Primary source: FLYBASE:FBgn0000463
Locus tag: Dmel_CG3619
See related: AllianceGenome:FB:FBgn0000463
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0495/20; 0926/11; 1053/14; 1119/09; 1304/03; 1423/11; 1440/11; 1485/04; anon-WO0118547.269; C1; CG3619; CT12133; D1; delta; delta D1; Deltal; Dl; DL; dmDelta; Dmel\CG3619; E(ls)2; EC3-5; l(3)05151; l(3)92Ab; l(3)j8C3
Summary: Enables Notch binding activity; glycosphingolipid binding activity; and receptor ligand activity. Involved in several processes, including animal organ morphogenesis; nervous system development; and oogenesis. Located in several cellular components, including apical cortex; cell surface; and cytoplasmic vesicle. Is integral component of membrane. Colocalizes with cytoplasmic vesicle. Is expressed in several structures, including extended germ band embryo; germ layer; gut section; head; and imaginal disc. Used to study cancer and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 92A1-92A2; 3-66 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19302731..19326217, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15128453..15151939, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Employ genome engineering to generate a functional optogenetic allele of the Notch ligand Delta (opto-Delta), which replaces both copies of the endogenous wild-type locus. Using clonal analysis, we show that optogenetic activation blocks Notch activation through cis-inhibition in signal-receiving cells.
Title: Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation.
Here we show that, in intestinal stem cell lineages in adult Drosophila, in which the Delta-Notch-signalling-guided progenitor cell differentiation into enterocytes is the default mode, the specification of enteroendocrine cells (EEs) is initiated by transient Scute activation in a process driven by transcriptional self-stimulation combined with a negative feedback regulation between Scute and Notch targets
Title: Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.
Delta-Notch dependent boundary formation in the Drosophila large intestine
Title: Modeling and analysis of the Delta-Notch dependent boundary formation in the Drosophila large intestine.
The authors found that Dl requires ubi for its full function, but can also signal in two ubi-independent modes, one dependent and one independent of Neur. Their analysis suggests that one important role of Dl protein ubiquitination by Mib1 is their release from cis-inhibitory interactions with Notch, enabling them to trans-activate Notch on adjacent cells.
Title: Ubiquitylation-independent activation of Notch signalling by Delta.
reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning.
Title: Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.
A new paramutation-like example at the Delta gene of Drosophila has been described.
Title: A new paramutation-like example at the Delta gene of Drosophila.
Binding of Notch to ligands of the Delta/DLL and Serrate/JAG families from neighboring cells leads to activation of the signaling pathway and is called trans-activation
Title: Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila.
miR-124 plays neuroprotective roles in Alzheimer's disease Drosophila by targeting Delta in Notch signaling pathway.
Title: The Role of miR-124 in Drosophila Alzheimer's Disease Model by Targeting Delta in Notch Signaling Pathway.
We further show that Notch in ORNs acts by both canonical cleavage-dependent and non-canonical cleavage-independent pathways. The Notch ligand Delta (Dl) in PNs switches the balance between the pathways.
Title: Notch is required in adult Drosophila sensory neurons for morphological and functional plasticity of the olfactory circuit.
Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium.
Title: Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IDA Inferred from Direct Assay more info	PubMed
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antennal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	TAS Traceable Author Statement more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	TAS Traceable Author Statement more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye retinal cell programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber stalk formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte localization involved in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in second mitotic wave involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta

Names: CG3619-PA; CG3619-PB; CG3619-PC; Delta-PA; Delta-PB; Delta-PC; complementation group 1; overflow

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

19302731..19326217 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057916.4 → NP_477264.1 delta, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477264.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2

UniProtKB/TrEMBL

A4V346

Related

FBpp0083153

Conserved Domains (3) summary

cd00054
Location:529 → 564

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:164 → 226

DSL; Delta serrate ligand

pfam07657
Location:23 → 96

MNNL; N terminus of Notch ligand
NM_001260264.2 → NP_001247193.1 delta, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2

UniProtKB/TrEMBL

A4V346

Conserved Domains (3) summary

cd00054
Location:529 → 564

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:164 → 226

DSL; Delta serrate ligand

pfam07657
Location:23 → 96

MNNL; N terminus of Notch ligand
NM_169853.3 → NP_732412.1 delta, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732412.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P10041, Q6T3F7, Q6T3G1, Q6T3G7, Q6T3G8, Q6T3H0, Q6T3H3, Q6T3I3, Q6T3I5, Q6T3I7, Q6T3J1, Q6T3J2, Q6T3J3, Q6T3J4, Q6T3K0, Q6T3K1, Q6T3K9, Q6T3L5, Q6T3L7, Q6T3L9, Q6T3M2, Q6T3M4, Q6T3M7, Q6T3N1, Q6T3N3, Q6T3N5, Q6T3N7, Q6T4M9, Q6T4N0, Q6T4N1, Q6T4N2, Q6T4N3, Q6T4N4, Q6T4N6, Q95RM9, Q99108, Q9VDY2

UniProtKB/TrEMBL

A4V346

Related

FBpp0083154

Conserved Domains (3) summary

cd00054
Location:529 → 564

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:164 → 226

DSL; Delta serrate ligand

pfam07657
Location:23 → 96

MNNL; N terminus of Notch ligand