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Ppcs Phosphopantothenoylcysteine synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42295, updated on 18-Sep-2024

Summary

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Official Symbol
Ppcsprovided by FlyBase
Official Full Name
Phosphopantothenoylcysteine synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0261285
Locus tag
Dmel_CG5629
See related
AllianceGenome:FB:FBgn0261285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.401; BcDNA:GH03502; CG5629; Dmel\CG5629; dPPCS; GH03502; PPCS
Summary
Predicted to enable phosphopantothenate--cysteine ligase activity. Involved in several processes, including chaeta development; lipid homeostasis; and oogenesis. Is expressed in adult head; larval midline neurons; midline primordium; and organism. Used to study dilated cardiomyopathy and neurodegenerative disease. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ppcs in Genome Data Viewer
Location:
91F3-91F4; 3-66 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19139054..19147910, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14964776..14973632, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 12a5 Neighboring gene Cytochrome P450 12a4 Neighboring gene antisense RNA:CR44107 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nanos

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. Mostert KJ, et al. ACS Chem Biol, 2021 Nov 19. PMID 34582681, Free PMC Article
  2. Stress affects the epigenetic marks added by natural transposable element insertions in Drosophila melanogaster. Guio L, et al. Sci Rep, 2018 Aug 15. PMID 30111890, Free PMC Article
  3. Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Iuso A, et al. Am J Hum Genet, 2018 Jun 7. PMID 29754768, Free PMC Article
  4. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
  5. Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Bogwitz MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16120680, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphopantothenate--cysteine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopantothenate--cysteine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopantothenate--cysteine ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber stalk formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived female germ-line cyst encapsulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian nurse cell to oocyte transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphopantothenoylcysteine synthetase
Names
4'-phosphopantothenoylcysteine synthetase
CG5629-PA
CG5629-PC
CG5629-PD
Ppcs-PA
Ppcs-PC
Ppcs-PD
NP_001303433.1
NP_650784.3
NP_732401.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19139054..19147910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169848.3 → NP_732401.1  phosphopantothenoylcysteine synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732401.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN99
    Related
    FBpp0083166
    Conserved Domains (1) summary
    PRK05579
    Location:26 → 257
    PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

  2. NM_142527.3 → NP_650784.3  phosphopantothenoylcysteine synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650784.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QD26
    Conserved Domains (1) summary
    cl04410
    Location:34 → 257
    DFP; DNA / pantothenate metabolizm flavoprotein

  3. NM_001316504.1 → NP_001303433.1  phosphopantothenoylcysteine synthetase, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN99
    Conserved Domains (1) summary
    PRK05579
    Location:26 → 257
    PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QD26 E2QD26
Q7KN99 Q7KN99
Q8T950 Q8T950

Gene LinkOut

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