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MAVS mitochondrial antiviral signaling protein [ Gallus gallus (chicken) ]

Gene ID: 422936, updated on 10-Oct-2024

Summary

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Symbol
MAVSprovided by CGNC
Full Name
mitochondrial antiviral signaling proteinprovided by CGNC
Primary source
CGNC:51863
See related
Ensembl:ENSGALG00010016469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MAVS in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (88125587..88133674, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (87928940..87937029, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 24 Neighboring gene microRNA 103a-2 Neighboring gene pantothenate kinase 2 Neighboring gene protein tyrosine phosphatase, receptor type A Neighboring gene mitochondrial ribosomal protein S26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens. Yu D, et al. Gene, 2014 Jul 25. PMID 24835312
  2. Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS. Yu L, et al. BMC Vet Res, 2017 Nov 13. PMID 29132350, Free PMC Article
  3. IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens. Cheng Y, et al. J Immunol, 2019 Oct 1. PMID 31366714
  4. Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2. Liniger M, et al. J Virol, 2012 Jan. PMID 22072756, Free PMC Article
  5. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IRF7 Is Involved in Both STING and MAVS Mediating IFN-beta Signaling in IRF3-Lacking Chickens.
    Title: IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens.
  2. Infectious bronchitis virus can cleave MAVS
    Title: Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
  3. a considerably high genetic variability of the MAVS gene, and the 3'-UTR variants had an ability to regulate mRNA expression. These results would cast some clues on understanding the potential role of MAVS on viral resistance in chicken
    Title: Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens.
  4. Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.
    Title: Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
mitochondrial antiviral-signaling protein
Names
CARDIF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012893.2 → NP_001012911.2  mitochondrial antiviral-signaling protein

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000077
    UniProtKB/TrEMBL
    A0A8V0YWE2, W0S6J0
    Conserved Domains (2) summary
    PHA03255
    Location:444 → 636
    PHA03255; BDLF3; Provisional
    cd08811
    Location:3 → 93
    CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    88125587..88133674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046940275.1 → XP_046796231.1  mitochondrial antiviral-signaling protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0YWE2

  2. XM_046940277.1 → XP_046796233.1  mitochondrial antiviral-signaling protein isoform X2

  3. XM_046940276.1 → XP_046796232.1  mitochondrial antiviral-signaling protein isoform X1

    UniProtKB/TrEMBL
    A0A8V0YWE2
    Related
    ENSGALP00010022935.1, ENSGALT00010039676.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    87928940..87937029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046916446.1 → XP_046772402.1  mitochondrial antiviral-signaling protein isoform X1

    UniProtKB/TrEMBL
    Q5F3P5

  2. XM_046916448.1 → XP_046772404.1  mitochondrial antiviral-signaling protein isoform X2

  3. XM_046916447.1 → XP_046772403.1  mitochondrial antiviral-signaling protein isoform X1

    UniProtKB/TrEMBL
    Q5F3P5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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