Smu1 Smu1 spliceosomal factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Smu1provided by FlyBase
Official Full Name: Smu1 spliceosomal factorprovided by FlyBase
Primary source: FLYBASE:FBgn0038666
Locus tag: Dmel_CG5451
See related: AllianceGenome:FB:FBgn0038666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5451; Dmel\CG5451; dsmu1
Summary: Involved in neuromuscular junction development; neuromuscular synaptic transmission; and terminal button organization. Located in cytoplasm and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 91E1-91E2; 3-65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18978980..18981324, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14804702..14807046, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of precatalytic spliceosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Smu1 spliceosomal factor

Names: CG5451-PA; CG5451-PB; CG5451-PC; SMU1 ortholog; Smu1-PA; Smu1-PB; Smu1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18978980..18981324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260260.1 → NP_001247189.1 Smu1 spliceosomal factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247189.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960P6, Q9VE18

Conserved Domains (4) summary

smart00668
Location:40 → 90

CTLH; C-terminal to LisH motif

cd00200
Location:214 → 508

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:218 → 256

7WD40; WD40 repeat [structural motif]

pfam17814
Location:7 → 36

LisH_TPL; LisH-like dimerisation domain
NM_001260261.1 → NP_001247190.1 Smu1 spliceosomal factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247190.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960P6, Q9VE18

Conserved Domains (4) summary

smart00668
Location:40 → 90

CTLH; C-terminal to LisH motif

cd00200
Location:214 → 508

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:218 → 256

7WD40; WD40 repeat [structural motif]

pfam17814
Location:7 → 36

LisH_TPL; LisH-like dimerisation domain
NM_142509.5 → NP_650766.1 Smu1 spliceosomal factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650766.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960P6, Q9VE18

Related

FBpp0083135

Conserved Domains (4) summary

smart00668
Location:40 → 90

CTLH; C-terminal to LisH motif

cd00200
Location:214 → 508

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:218 → 256

7WD40; WD40 repeat [structural motif]

pfam17814
Location:7 → 36

LisH_TPL; LisH-like dimerisation domain