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Smu1 Smu1 spliceosomal factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42272, updated on 18-Sep-2024

Summary

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Official Symbol
Smu1provided by FlyBase
Official Full Name
Smu1 spliceosomal factorprovided by FlyBase
Primary source
FLYBASE:FBgn0038666
Locus tag
Dmel_CG5451
See related
AllianceGenome:FB:FBgn0038666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5451; Dmel\CG5451; dsmu1
Summary
Involved in neuromuscular junction development; neuromuscular synaptic transmission; and terminal button organization. Located in cytoplasm and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human SMU1 (SMU1 DNA replication regulator and spliceosomal factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Smu1 in Genome Data Viewer
Location:
91E1-91E2; 3-65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18978980..18981324, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14804702..14807046, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small ribonucleoprotein particle U1 subunit C Neighboring gene eucalyptus Neighboring gene deoxyribonucleoside kinase Neighboring gene GUK-holder

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag. Beck ES, et al. J Neurosci, 2012 May 16. PMID 22593074, Free PMC Article
  2. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article
  3. Alternative splicing in Drosophila neuronal development. Mohr C, et al. J Neurogenet, 2014 Sep-Dec. PMID 24957133
  4. The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance. Ariyapala IS, et al. Genetics, 2022 Sep 30. PMID 35762963, Free PMC Article
  5. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Cheng LW, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157870, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in terminal button organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Smu1 spliceosomal factor
Names
CG5451-PA
CG5451-PB
CG5451-PC
SMU1 ortholog
Smu1-PA
Smu1-PB
Smu1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18978980..18981324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260260.1 → NP_001247189.1  Smu1 spliceosomal factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960P6, Q9VE18
    Conserved Domains (4) summary
    smart00668
    Location:40 → 90
    CTLH; C-terminal to LisH motif
    cd00200
    Location:214 → 508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:218 → 256
    7WD40; WD40 repeat [structural motif]
    pfam17814
    Location:7 → 36
    LisH_TPL; LisH-like dimerisation domain

  2. NM_001260261.1 → NP_001247190.1  Smu1 spliceosomal factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247190.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960P6, Q9VE18
    Conserved Domains (4) summary
    smart00668
    Location:40 → 90
    CTLH; C-terminal to LisH motif
    cd00200
    Location:214 → 508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:218 → 256
    7WD40; WD40 repeat [structural motif]
    pfam17814
    Location:7 → 36
    LisH_TPL; LisH-like dimerisation domain

  3. NM_142509.5 → NP_650766.1  Smu1 spliceosomal factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650766.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960P6, Q9VE18
    Related
    FBpp0083135
    Conserved Domains (4) summary
    smart00668
    Location:40 → 90
    CTLH; C-terminal to LisH motif
    cd00200
    Location:214 → 508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:218 → 256
    7WD40; WD40 repeat [structural motif]
    pfam17814
    Location:7 → 36
    LisH_TPL; LisH-like dimerisation domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VE18 Q9VE18

Gene LinkOut

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