U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sgsh N-sulfoglucosamine sulfohydrolase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42266, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Sgshprovided by FlyBase
Official Full Name
N-sulfoglucosamine sulfohydrolaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038660
Locus tag
Dmel_CG14291
See related
AllianceGenome:FB:FBgn0038660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14291; Dmel\CG14291; SGSH
Summary
Predicted to enable N-sulfoglucosamine sulfohydrolase activity. Predicted to be involved in glycosaminoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Is expressed in several structures, including antennal primordium; anterior-posterior subdivision of organism; cuboidal/columnar epithelium; head epidermis primordium; and sense organ. Used to study mucopolysaccharidosis type IIIA. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sgsh in Genome Data Viewer
Location:
91D4-91D4; 3-65 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18911053..18912922, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14736775..14738644, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Endophilin A Neighboring gene Xrp1 Neighboring gene Mitochondrial pyruvate carrier

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster. Jumbo-Lucioni P, et al. BMC Genomics, 2012 Nov 22. PMID 23171078, Free PMC Article
  2. Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity. Mallik M, et al. J Cell Biol, 2018 Nov 5. PMID 30209068, Free PMC Article
  3. Neuronal-specific impairment of heparan sulfate degradation in Drosophila reveals pathogenic mechanisms for Mucopolysaccharidosis type IIIA. Webber DL, et al. Exp Neurol, 2018 May. PMID 29408731
  4. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. Xia Q, et al. EMBO J, 2016 Jan 18. PMID 26702100, Free PMC Article
  5. Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Yeung K, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295802, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-sulfoglucosamine sulfohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
N-sulfoglucosamine sulfohydrolase
Names
CG14291-PA
Sgsh-PA
NP_650760.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18911053..18912922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142503.5 → NP_650760.1  N-sulfoglucosamine sulfohydrolase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE24
    Related
    FBpp0083138
    Conserved Domains (2) summary
    COG3119
    Location:17 → 476
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16027
    Location:22 → 471
    SGSH; N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VE24 Q9VE24

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous