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WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Gallus gallus (chicken) ]

Gene ID: 422097, updated on 17-Aug-2024

Summary

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Official Symbol
WFIKKN2provided by CGNC
Official Full Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by CGNC
Primary source
CGNC:5567
See related
Ensembl:ENSGALG00010029277
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See WFIKKN2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
2
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (10730342..10735809, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (10330796..10336264, complement)

Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene transducer of ERBB2, 1 Neighboring gene ankyrin repeat domain-containing protein 40-like Neighboring gene LUC7 like 3 pre-mRNA splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Names
WFIKKN-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10730342..10735809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_420100.7 → XP_420100.2  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

    UniProtKB/TrEMBL
    A0A8V1AMY4, E1C6W9
    Related
    ENSGALP00010043495.1, ENSGALT00010070804.1
    Conserved Domains (6) summary
    smart00131
    Location:321 → 373
    KU; BPTI/Kunitz family of serine protease inhibitors
    cd00104
    Location:135 → 171
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:449 → 557
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380 → 431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:39 → 88
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd05765
    Location:207 → 301
    IgI_3_WFIKKN-like; Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10330796..10336264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040686658.2 → XP_040542592.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

    UniProtKB/TrEMBL
    A0A8V1AMY4, E1C6W9
    Conserved Domains (6) summary
    smart00131
    Location:321 → 373
    KU; BPTI/Kunitz family of serine protease inhibitors
    cd00104
    Location:135 → 171
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:449 → 557
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:380 → 431
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:39 → 88
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd05765
    Location:207 → 301
    IgI_3_WFIKKN-like; Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version

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